PVRL2
Reactivity: Human
FACS, ELISA, IP
Host: Mouse
Monoclonal
B-C12
unconjugated
Application Notes
Immunohistochemistry: (frozen sections) Use at a 1:10 dilution. Flow cytometry: Use at a 1:10 dilution. Western blot: Use at a 1:10 dilution. Fixation with PFA or acetone/methanol is recommended.
Restrictions
For Research Use only
Format
Liquid
Buffer
1 mL of 100 µg/mL
Storage
4 °C
Target
PVRL2
(Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2))
Nectin (originally isolated as poliovirus receptor- related protein (PRR)) is a cell-cell adhesion molecule of the immunoglobulin supergene family. Nectin is co-localized with afadin at cadherin-based cell-cell adherence juctions in various tissues and cell lines. The nectin family consists of nectin-1, nectin-2 and nectin-3. Nectin-2 is a plasma membrane adhesion molecule localized at adherens junctions which is widely expressed in various cells lines including neuronal, endothelial, epithelial and hematopoietic cells. Next to its role in adherens junctions it functions as alphaherpus virus receptor and acts also as intercellular adhesion molecule and pseudorabies virus receptor. Disruption of mouse nectin-2 leads to infertility of male mice. Synonyms: PRR2, CD112