STAT6 antibody

Catalog No. ABIN920869

Product Details anti-STAT6 Antibody

Target: STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STAT6 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: Recognizes STAT6.

Purification: Purified by antigen-affinity chromatography.

Immunogen: Peptide mapped to the carboxy-terminus of human STAT6.

Application Details

Application Notes: Western blot: Use at 10 myL per 5 mL antibody dilution buffer for each mini-gel.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 200 µL containing rabbit IgG in PBS, pH 7.2, with 0.09% sodium azide and 50% glycerol and protein stabilizer.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for STAT6

Target: STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))

Alternative Name: STAT6 (STAT6 Products)

Synonyms: D12S1644 antibody, IL-4-STAT antibody, STAT6B antibody, STAT6C antibody, signal transducer and activator of transcription 6 antibody, signal transducer and activator of transcription 6-like antibody, STAT6 antibody, Stat6 antibody, LOC100859543 antibody

Background: STAT6 is a 94 kD member of the STAT (signal transducer and activator of transcription) protein family that is phosphorylated in response to cytokine receptor-associated kinase activity. Phosphorylation of STAT6 induces nuclear translocation to activate transcription. STAT6 is expressed in olfactory cells, bronchial epithelium, adrenal gland, B cells, mast cells, Wilm's tumors and some solid tumors. STAT6 forms homo- and heterotrimers and has been shown to be important in IL-4 mediated biological responses, the induction of Bcl-2 and Bcl-XL, and may also be involved in TH2 differentiation and immunoglobulin class switching. STAT6 is phosphorylated in response to IL-4, IL-13, IL-3 and has been shown to interact with nuclear co-activator 1 (NCOA1), the CREB binding SRC-1 protein, and p300/CBP. Synonyms: Anti-signal transducer and activator of transcription 2, anti-interferon alpha induced transcriptional activator.

Molecular Weight: 94 kDa

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response