DIABLO antibody (C-Term)

Catalog No. ABIN925989

Product Details anti-DIABLO Antibody

Target: DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))

Binding Specificity: C-Term

Reactivity: Human, Cow, Dog, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DIABLO antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Dog (Canine), Pig (Porcine), Cow (Bovine)

Immunogen: DIABLO antibody was raised in rabbit using the C terminal of DIABLO as the immunogen

Application Details

Application Notes: WB: 0.3125 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

DIABLO Blocking Peptide, catalog no. 33R-5520, is also available for use as a blocking control in assays to test for specificity of this DIABLO antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 100 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for DIABLO

Target: DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))

Alternative Name: DIABLO (DIABLO Products)

Synonyms: smac antibody, smac3 antibody, diablo-s antibody, 0610041G12Rik antibody, 1700006L01Rik antibody, AU040403 antibody, Smac antibody, DFNA64 antibody, SMAC antibody, DBO antibody, XSmac antibody, diablo, IAP-binding mitochondrial protein antibody, diablo IAP-binding mitochondrial protein antibody, diablo, IAP-binding mitochondrial protein L homeolog antibody, diablo antibody, Diablo antibody, DIABLO antibody, diablo.L antibody

Background: DIABLO is an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Several alternatively spliced transcript variants that encode distinct isoforms have been described for this gene but the validity of some transcripts, and their predicted ORFs, has not been determined conclusively. Synonyms: Polyclonal DIABLO antibody, Anti-DIABLO antibody, diablo homolog, Drosophila antibody.

Pathways: Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity