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Actin-Like 7A (ACTL7A) (AA 48-75), (N-Term) antibody

Details for Product No. ABIN950263, Supplier: Log in to see
Antigen
  • Arp7a
  • T-actin 2
  • Tact2
Epitope
N-Term, AA 48-75
17
15
3
2
2
1
1
Reactivity
Human
48
8
5
Host
Rabbit
46
4
Clonality
Polyclonal
Conjugate
Un-conjugated
5
5
5
2
2
2
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
43
31
7
5
1
1
Supplier
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Immunogen KLH conjugated synthetic peptide between 48-75 amino acids from the N-terminal region of human ACTL7A
Isotype Ig
Specificity This antibody reacts to ACTL7A.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name ACTL7A (ACTL7A Antibody Abstract)
Background ACTL7A is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. ACTL7A (ACTL7A), and related gene, ACTL7B, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7A gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. The ACTL7A gene is expressed in a wide variety of adult tissues, however, its exact function is not known.Synonyms: Actin-like protein 7A, Actin-like-7-alpha
Gene ID 10881
NCBI Accession NP_006678
Research Area Signaling, Cytoskeleton, Microfilaments
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-Actin-Like 7A (ACTL7A) (AA 48-75), (N-Term) antibody (ABIN950263) ACTL7A Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35µg/la...
Background publications Aberg, Sun, Smelser, Indugula, Tsai, Steele, Tuitele, Deka, McGarvey, Weeks: "Applying novel genome-wide linkage strategies to search for loci influencing type 2 diabetes and adult height in American Samoa." in: Human biology, Vol. 80, Issue 2, pp. 99-123, 2008

Humphray, Oliver, Hunt, Plumb, Loveland, Howe, Andrews, Searle, Hunt, Scott, Jones, Ainscough, Almeida, Ambrose, Ashwell, Babbage, Babbage, Bagguley, Bailey, Banerjee, Barker, Barlow, Bates, Beasley et al.: "DNA sequence and analysis of human chromosome 9. ..." in: Nature, Vol. 429, Issue 6990, pp. 369-74, 2004