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ALOX12B antibody (Arachidonate 12-Lipoxygenase, 12R Type) (AA 629-660)

Details for Product anti-ALOX12B Antibody No. ABIN950354, Supplier: Log in to see
Antigen
  • 12R-LOX
  • ALOX12B
  • Aloxe2
  • ARCI2
  • e-LOX2
  • MGC85124
  • MGC107915
Epitope
AA 629-660, C-Term
15
15
3
2
1
Reactivity
Human
23
1
1
Host
Rabbit
19
4
Clonality
Polyclonal
Conjugate
This ALOX12B antibody is un-conjugated
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
20
17
15
14
3
1
1
Supplier
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Immunogen KLH conjugated synthetic peptide between 629-660 amino acids from the C-terminal region of human ALOX12B
Isotype Ig
Specificity This antibody reacts to ALOX12B.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name ALOX12B (ALOX12B Antibody Abstract)
Background This gene encodes an enzyme involved in the converstion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene are associated with nonbullous congenital ichthyosiform erythroderma.Synonyms: 12R type, 12R-LOX, 12R-lipoxygenase, Arachidonate 12-lipoxygenase
Gene ID 242
NCBI Accession NP_001130
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-ALOX12B antibody (Arachidonate 12-Lipoxygenase, 12R Type) (AA 629-660) (ABIN950354) ALOX12B Antibody (C-term) flow cytometric analysis of A549 cells (right histogram) co...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-ALOX12B antibody (Arachidonate 12-Lipoxygenase, 12R Type) (AA 629-660) (ABIN950354) ALOX12B antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffi...
Western Blotting (WB) image for anti-ALOX12B antibody (Arachidonate 12-Lipoxygenase, 12R Type) (AA 629-660) (ABIN950354) ALOX12B Antibody (C-term) western blot analysis in A549 cell line lysates (35µg/lane)...
Background publications Vahlquist, Bygum, Gånemo, Virtanen, Hellström-Pigg, Strauss, Brandrup, Fischer: "Genotypic and clinical spectrum of self-improving collodion ichthyosis: ALOX12B, ALOXE3, and TGM1 mutations in Scandinavian patients." in: The Journal of investigative dermatology, Vol. 130, Issue 2, pp. 438-43, 2010 (PubMed).

Han, Lan, Park, Lee, Park, Ahn, Shin, Kang, Koo, Seo, Choi, Ahn, Chanock, Kim, Rothman, Kang: "Polymorphisms in innate immunity genes and risk of childhood leukemia." in: Human immunology, Vol. 71, Issue 7, pp. 727-30, 2010 (PubMed).

Rajaraman, Brenner, Neta, Pfeiffer, Wang, Yeager, Thomas, Fine, Linet, Rothman, Chanock, Inskip: "Risk of meningioma and common variation in genes related to innate immunity." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 5, pp. 1356-61, 2010 (PubMed).

Agarwal, Achari, Praveen, Roy, Reddy, Reddanna: "Inhibition of 12-LOX and COX-2 reduces the proliferation of human epidermoid carcinoma cells (A431) by modulating the ERK and PI3K-Akt signalling pathways." in: Experimental dermatology, Vol. 18, Issue 11, pp. 939-46, 2009 (PubMed).

Rajaraman, Brenner, Butler, Wang, Pfeiffer, Ruder, Linet, Yeager, Wang, Orr, Fine, Kwon, Thomas, Rothman, Inskip, Chanock: "Common variation in genes related to innate immunity and risk of adult glioma." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 5, pp. 1651-8, 2009 (PubMed).