ACTN2 antibody (Actinin, alpha 2) (C-Term)

Details for Product anti-ACTN2 Antibody No. ABIN950370, Supplier: Log in to see
Antigen
  • MGC89234
  • ACTN2
  • 1110008F24Rik
  • CMD1AA
  • wu:fd44c03
  • zgc:123223
  • actinin, alpha 2
  • actinin alpha 2
  • actn2
  • ACTN2
  • Actn2
Alternatives
anti-Mouse (Murine) ACTN2 antibody for ELISA
Epitope
C-Term, AA 750-779
19
10
8
5
5
4
3
3
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
60
57
32
13
11
7
7
5
5
5
4
2
2
2
2
2
2
Host
Rabbit
70
13
Clonality
Polyclonal
Conjugate
This ACTN2 antibody is un-conjugated
4
3
2
2
2
2
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
74
27
22
20
16
11
4
4
3
2
Options
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Immunogen KLH conjugated synthetic peptide between 750-779 amino acids from the C-terminal region of human ACTN2
Isotype Ig
Specificity This antibody reacts to Alpha-actinin-2.
Cross-Reactivity (Details) Species reactivity (tested):Mouse.
Purification Affinity chromatography on Protein A
Alternative Name alpha-Actinin-2 / ACTN2 (ACTN2 Antibody Abstract)
Background Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles.Synonyms: Alpha actinin skeletal muscle isoform 2, F-actin cross-linking protein
Gene ID 88
NCBI Accession NP_001094
Pathways Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Negative Regulation of Transporter Activity
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-ACTN2 antibody (Actinin, alpha 2) (C-Term) (ABIN950370) ACTN2 Antibody (C-term) western blot analysis in mouse heart tissue lysates (35µg/lan...
Background publications Chiu, Bagnall, Ingles, Yeates, Kennerson, Donald, Jormakka, Lind, Semsarian: "Mutations in alpha-actinin-2 cause hypertrophic cardiomyopathy: a genome-wide analysis." in: Journal of the American College of Cardiology, Vol. 55, Issue 11, pp. 1127-35, 2010 (PubMed).

Saus, Brunet, Armengol, Alonso, Crespo, Fernández-Aranda, Guitart, Martín-Santos, Menchón, Navinés, Soria, Torrens, Urretavizcaya, Vallès, Gratacòs, Estivill: "Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients." in: Journal of psychiatric research, Vol. 44, Issue 14, pp. 971-8, 2010 (PubMed).

Zimmerman, Cox, Lakdawala, Cirino, Mancini-DiNardo, Clark, Leon, Duffy, White, Baxter, Alaamery, Farwell, Weiss, Seidman, Seidman, Ho, Rehm, Funke: "A novel custom resequencing array for dilated cardiomyopathy." in: Genetics in medicine : official journal of the American College of Medical Genetics, Vol. 12, Issue 5, pp. 268-78, 2010 (PubMed).

Joslyn, Ravindranathan, Brush, Schuckit, White: "Human variation in alcohol response is influenced by variation in neuronal signaling genes." in: Alcoholism, clinical and experimental research, Vol. 34, Issue 5, pp. 800-12, 2010 (PubMed).

Hanna, Kruskal, Ezekowitz, Bloom, Collier: "Role of macrophage oxidative burst in the action of anthrax lethal toxin." in: Molecular medicine (Cambridge, Mass.), Vol. 1, Issue 1, pp. 7-18, 1996 (PubMed).