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ACTN2 antibody (Actinin, alpha 2) (C-Term)

Details for Product anti-ACTN2 Antibody No. ABIN950370, Supplier: Log in to see
Antigen
  • MGC89234
  • ACTN2
  • 1110008F24Rik
  • CMD1AA
  • wu:fd44c03
  • zgc:123223
Epitope
C-Term, AA 750-779
24
15
6
5
3
2
2
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
48
46
20
7
6
5
5
3
3
1
Host
Rabbit
66
11
Clonality
Polyclonal
Conjugate
This ACTN2 antibody is un-conjugated
4
3
2
2
2
2
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
62
28
15
15
13
9
5
3
1
Supplier
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Immunogen KLH conjugated synthetic peptide between 750-779 amino acids from the C-terminal region of human ACTN2
Isotype Ig
Specificity This antibody reacts to Alpha-actinin-2.
Cross-Reactivity (Details) Species reactivity (tested):Mouse.
Purification Affinity chromatography on Protein A
Alternative Name alpha-Actinin-2 / ACTN2 (ACTN2 Antibody Abstract)
Background Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles.Synonyms: Alpha actinin skeletal muscle isoform 2, F-actin cross-linking protein
Gene ID 88
NCBI Accession NP_001094
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-ACTN2 antibody (Actinin, alpha 2) (C-Term) (ABIN950370) ACTN2 Antibody (C-term) western blot analysis in mouse heart tissue lysates (35µg/lan...
Background publications Zimmerman, Cox, Lakdawala et al.: "A novel custom resequencing array for dilated cardiomyopathy." in: Genetics in medicine : official journal of the American College of Medical Genetics, Vol. 12, Issue 5, pp. 268-78, 2010 (PubMed).

Saus, Brunet, Armengol et al.: "Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients." in: Journal of psychiatric research, Vol. 44, Issue 14, pp. 971-8, 2010 (PubMed).

Joslyn, Ravindranathan, Brush et al.: "Human variation in alcohol response is influenced by variation in neuronal signaling genes." in: Alcoholism, clinical and experimental research, Vol. 34, Issue 5, pp. 800-12, 2010 (PubMed).

Chiu, Bagnall, Ingles et al.: "Mutations in alpha-actinin-2 cause hypertrophic cardiomyopathy: a genome-wide analysis." in: Journal of the American College of Cardiology, Vol. 55, Issue 11, pp. 1127-35, 2010 (PubMed).

Hanna, Kruskal, Ezekowitz et al.: "Role of macrophage oxidative burst in the action of anthrax lethal toxin." in: Molecular medicine (Cambridge, Mass.), Vol. 1, Issue 1, pp. 7-18, 1996 (PubMed).