MUC1 antibody (AA 1209-1239)
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- Target See all MUC1 Antibodies
- MUC1 (Mucin 1 (MUC1))
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Binding Specificity
- AA 1209-1239
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MUC1 antibody is un-conjugated
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Specificity
- This antibody recognizes human CD227 / Mucin-1 / MUC1.
- Purification
- Purified through a Protein A column followed by peptide affinity purification
- Immunogen
- Synthetic peptide - KLH conjugated - corresponding to human CD227 / Mucin-1 / MUC1 (between 1209-1239aa)
- Isotype
- Ig Fraction
- Top Product
- Discover our top product MUC1 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.25 mg/mL
- Buffer
- PBS with 0.09 % (W/V) Sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- MUC1 (Mucin 1 (MUC1))
- Alternative Name
- CD227 / Mucin-1 / MUC1 (MUC1 Products)
- Synonyms
- CA 15-3 antibody, CD227 antibody, EMA antibody, H23AG antibody, KL-6 antibody, MAM6 antibody, MCKD1 antibody, MUC-1 antibody, MUC-1/SEC antibody, MUC-1/X antibody, MUC1/ZD antibody, PEM antibody, PEMT antibody, PUM antibody, Muc-1 antibody, mucin 1, cell surface associated antibody, mucin 1, transmembrane antibody, MUC1 antibody, Muc1 antibody
- Background
- The MUC1 gene is a member of the mucin family and encodes a membrane bound, glyco- sylated phosphoprotein anchored to the apical surface of many epithelia by a transmem- brane domain, with the degree of glycosylation varying with cell type. It includes a 20aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Its overexpression, aberrant intracellular localization and changes in glycosylation have been associated with carcino- mas. Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length nature of only some has been determined.Synonyms: Breast carcinoma-associated antigen DF3, CA 15-3, Carcinoma-associated mucin, DF3, EMA, Episialin, H23AG, MUC-1, PEMT, PUM, Peanut-reactive urinary mucin, Polymorphic epithelial mucin, Tumor-associated epithelial membrane antigen, Tumor-associated mucin
- Molecular Weight
- 122102 Da
- Gene ID
- 4582
- NCBI Accession
- NP_001018016
- Pathways
- Negative Regulation of intrinsic apoptotic Signaling
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