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CD27 antibody (CD27 Molecule)

Details for Product anti-CD27 Antibody No. ABIN951256, Supplier: Log in to see
Antigen
  • S152
  • S152. LPFS2
  • T14
  • Tnfrsf7
  • TNFRSF7
  • Tp55
Reactivity
Mouse (Murine)
405
160
61
4
4
4
2
Host
Hamster
254
85
60
42
31
5
Clonality (Clone)
Monoclonal ()
Conjugate
This CD27 antibody is un-conjugated
50
50
30
23
12
12
11
10
10
8
7
7
6
6
6
6
6
6
6
5
4
4
4
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
387
73
65
53
42
40
26
22
19
12
8
8
4
2
2
2
2
1
1
1
1
1
Supplier
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Available images

Immunogen MCD27 tag expressing clones AR0524 and AR0530 from Armenian Hamster spleen.
Clone LG-3A10
Isotype IgG1
Specificity Recognizes Mouse CD27 receptor.
Cross-Reactivity (Details) Species reactivity (tested):Mouse.
Purification Protein G Chromatography.
Alternative Name CD27 (CD27 Antibody Abstract)
Background CD27 is part of the Tumor Necrosis Factor (TNF) family of receptors and is lymphocyte specific. Murine CD27 is expressed on the great majority of both and T lymphocytes, on a small population of peripheral B cells and on a very small subset of B220+ cells in the bone marrow. Murine CD27 is found on all thymocytes except a subset of CD4-CD8- precursors. There are two known basic functions of CD27 signaling. First, the binding of CD27 to CD70, a protein which is also expressed in T and B cells, provides costimulatory signals in lymphocyte proliferation and immunoglobulin production. Second, the association of CD27 with intracellular Siva, a proapoptotic protein, results in the induction of apoptotic events.Synonyms: CD27L receptor, T-cell activation antigen CD27, T14, TNFRSF7, Tumor necrosis factor receptor superfamily member 7
Gene ID 21940
NCBI Accession NP_001028298
UniProt P41272
Research Area Immunology, Adaptive Immunity, Hematopoietic Progenitors, Cytokines, Innate Immunity, CD Antigens, Surface Receptors of Immune Cells
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-CD27 antibody (CD27 Molecule) (ABIN951256) anti-CD27 Molecule (CD27) antibody
Background publications Henke, Launhardt, Klement, Stelzner, Zell, Munder: "Apoptosis in coxsackievirus B3-caused diseases: interaction between the capsid protein VP2 and the proapoptotic protein siva." in: Journal of virology, Vol. 74, Issue 9, pp. 4284-90, 2000 (PubMed).

Gravestein, Nieland, Kruisbeek, Borst: "Novel mAbs reveal potent co-stimulatory activity of murine CD27." in: International immunology, Vol. 7, Issue 4, pp. 551-7, 1995 (PubMed).