TLR9 antibody
-
- Target See all TLR9 Antibodies
- TLR9 (Toll-Like Receptor 9 (TLR9))
-
Reactivity
- Human, Mouse, Rat
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This TLR9 antibody is un-conjugated
-
Application
- Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Specificity
- This antibody detects TLR9. Located in the membrane, and highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver (6).
- Purification
- Purified
- Immunogen
- Peptide corresponding to 15 amino acids near the center of human TLR9
- Isotype
- IgG
- Top Product
- Discover our top product TLR9 Primary Antibody
-
-
- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Buffer
- Phosphate buffered saline with 0.02 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- -20 °C
- Storage Comment
- Store the antibody (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
-
- Target
- TLR9 (Toll-Like Receptor 9 (TLR9))
- Alternative Name
- CD289 / TLR9 (TLR9 Products)
- Synonyms
- CD289 antibody, toll like receptor 9 antibody, toll-like receptor 9 antibody, TLR9 antibody, Tlr9 antibody
- Background
- Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). TLR9 forms a subfamily along with TLR7 and TLR8 that recognize viral RNA and CpG DNA sequences (3) and are localized in intracellular acidic compartments such as the phagolysosome (4). Unlike other TLRs which act through adaptor molecules such as TOLLIP, TIRAP, TRIF, and MyD88 to activate various kinases and transcription factors to respond to potential infection (5), TLR9 is strictly dependent on MyD88 (3).Synonyms: Toll-like receptor 9, UNQ5798/PRO19605
- Gene ID
- 54106
- NCBI Accession
- NP_059138
- UniProt
- Q9NR96
- Pathways
- TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
-