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TLR9 antibody (Toll-Like Receptor 9)

Details for Product anti-TLR9 Antibody No. ABIN951281, Supplier: Log in to see
Antigen
  • CD289
  • toll-like receptor 9
  • TLR9
  • Tlr9
Alternatives
anti-Human TLR9 antibody for Immunohistochemistry (Frozen Sections)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
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Host
Rabbit
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3
Clonality
Polyclonal
Conjugate
This TLR9 antibody is un-conjugated
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25
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6
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Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
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Options
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Immunogen Peptide corresponding to 15 amino acids near the center of human TLR9
Isotype IgG
Specificity This antibody detects TLR9. Located in the membrane, and highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver (6).
Purification Purified
Alternative Name CD289 / TLR9 (TLR9 Antibody Abstract)
Background Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). TLR9 forms a subfamily along with TLR7 and TLR8 that recognize viral RNA and CpG DNA sequences (3) and are localized in intracellular acidic compartments such as the phagolysosome (4). Unlike other TLRs which act through adaptor molecules such as TOLLIP, TIRAP, TRIF, and MyD88 to activate various kinases and transcription factors to respond to potential infection (5), TLR9 is strictly dependent on MyD88 (3).Synonyms: Toll-like receptor 9, UNQ5798/PRO19605
Gene ID 54106
NCBI Accession NP_059138
UniProt Q9NR96
Research Area Signaling, Immunology, Inflammation
Pathways TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer Phosphate buffered saline with 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
Supplier Images
 image for anti-TLR9 antibody (Toll-Like Receptor 9) (ABIN951281) anti-Toll-Like Receptor 9 (TLR9) antibody
Background publications Nishiya, DeFranco: "Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors." in: The Journal of biological chemistry, Vol. 279, Issue 18, pp. 19008-17, 2004 (PubMed).

Wagner: "The immunobiology of the TLR9 subfamily." in: Trends in immunology, Vol. 25, Issue 7, pp. 381-6, 2004 (PubMed).

McGettrick, ONeill: "The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction." in: Molecular immunology, Vol. 41, Issue 6-7, pp. 577-82, 2004 (PubMed).

Takeda, Kaisho, Akira: "Toll-like receptors." in: Annual review of immunology, Vol. 21, pp. 335-76, 2003 (PubMed).

Janeway, Medzhitov: "Innate immune recognition." in: Annual review of immunology, Vol. 20, pp. 197-216, 2002 (PubMed).