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FLIP antibody (Middle Region)
CFLAR
Reactivity: Human
WB, IHC (p), FACS, EIA
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-FLIP Antibody
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Target
See all FLIP (CFLAR) Antibodies
FLIP (CFLAR)
(CASP8 and FADD-Like Apoptosis Regulator (CFLAR))
Binding Specificity
All epitopes for FLIP antibodies
AA 152-182, Middle Region
Reactivity
All reactivities for FLIP antibodies
Human
Host
All hosts for FLIP antibodies
Rabbit
Clonality
All clonalities for FLIP antibodies
Polyclonal
Conjugate
All conjugates for FLIP antibodies
This FLIP antibody is un-conjugated
Application
All applications for FLIP antibodies
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)
Specificity
This antibody reacts to CFLAR.
Cross-Reactivity (Details)
Species reactivity (tested):Human.
Purification
Saturated Ammonium Sulfate (SAS) precipitation
Immunogen
KLH conjugated synthetic peptide between 152~182 amino acids from the Center region of human CFLAR
Isotype
Ig Fraction
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Discover our top product CFLAR Primary Antibody
Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
0.25 mg/mL
Buffer
PBS, 0.09 % (W/V) sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for FLIP
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Target
FLIP (CFLAR)
(CASP8 and FADD-Like Apoptosis Regulator (CFLAR))
Alternative Name
CFLAR / Casper / I-FLICE (CFLAR Products )
Synonyms
Clarp1 antibody, cflar antibody, CFLAR antibody, FLIP antibody, CASH antibody, CASP8AP1 antibody, CLARP antibody, Casper antibody, FLAME antibody, FLAME-1 antibody, FLAME1 antibody, I-FLICE antibody, MRIT antibody, c-FLIP antibody, c-FLIPL antibody, c-FLIPR antibody, c-FLIPS antibody, 2310024N18Rik antibody, A430105C05Rik antibody, Cash antibody, ENSMUSG00000072980 antibody, Flip antibody, Gm9845 antibody, c-Flip antibody, CASP8 and FADD-like apoptosis regulator a antibody, CASP8 and FADD like apoptosis regulator antibody, CASP8 and FADD like apoptosis regulator S homeolog antibody, CASP8 and FADD-like apoptosis regulator antibody, cflara antibody, CFLAR antibody, cflar antibody, cflar.S antibody, Cflar antibody
Background
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. It acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. It lacks enzymatic (caspase) activity.Synonyms: CASH, CASP8 and FADD-like apoptosis regulator, CASP8AP1, CLARP, Caspase homolog, Caspase-eight-related protein, Caspase-like apoptosis regulatory protein, Cellular FLICE-like inhibitory protein, FADD-like antiapoptotic molecule 1, FLAME-1, Inhibitor of FLICE, MACH-related inducer of toxicity, MRIT, Usurpin, c-FLIP
Molecular Weight
55344 Da
Gene ID
8837
NCBI Accession
NP_001120655
Pathways
Apoptosis , Regulation of Muscle Cell Differentiation , Skeletal Muscle Fiber Development
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