Cyclin H (CCNH) (N-Term), (AA 31-60) antibody

Details for Product No. ABIN951761
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Antigen
Synonyms zgc:114132, cak, p34, p37, Cych, ACYPI004637, ccnh, Cyclin-H, 142767_at, CG7405, Dmel\\CG7405, CAK, 6330408H09Rik, AI661354, AV102684, AW538719, ccnh-A
Epitope
N-Term, AA 31-60
(23), (9), (9), (8), (5), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(91), (47), (43), (15), (14), (12), (7), (1)
Host
Rabbit
(83), (16)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(84), (44), (31), (27), (14), (10), (9), (7), (6), (2), (2), (2), (1)
Pubmed 5 references available
Quantity 0.4 mL
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Catalog No. ABIN951761
357.50 $
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Immunogen KLH conjugated synthetic peptide between 31-60 amino acids from the N-terminal region of human CCNH
Isotype Ig
Specificity This antibody reacts to CCNH.
Cross-Reactivity (Details) Species reactivity (tested):Mouse.
Purification Saturated Ammonium Sulfate (SAS) precipitation
Alternative Name Cyclin H
Background The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.Synonyms: CCNH, Cyclin-H, MO15-associated protein, p34, p37
Molecular Weight 37643 Da
Gene ID 902
NCBI Accession NP_001230
Research Area Chromatin and Nuclear Signaling, Cell Cycle
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Sugiyama, Masuda, Shinoda et al.: "Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 6, pp. 1103-9, 2007 (PubMed).

Kweekel, Antonini, Nortier et al.: "Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array." in: British journal of cancer, Vol. 101, Issue 2, pp. 357-62, 2009 (PubMed).

Hosgood, Menashe, He et al.: "PTEN identified as important risk factor of chronic obstructive pulmonary disease." in: Respiratory medicine, Vol. 103, Issue 12, pp. 1866-70, 2009 (PubMed).

Guey, García-Closas, Murta-Nascimento et al.: "Genetic susceptibility to distinct bladder cancer subphenotypes." in: European urology, Vol. 57, Issue 2, pp. 283-92, 2010 (PubMed).

Young, Hopkins, Hay et al.: "A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers." in: Postgraduate medical journal, Vol. 85, Issue 1008, pp. 515-24, 2009 (PubMed).

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