MDS1 and EVI1 Complex Locus (MECOM) (AA 80-109), (Middle Region) antibody

Details for Product No. ABIN953364, Supplier: Log in to see
Antigen
  • evi1
  • im:7140716
  • prdm3
  • EVI1
  • AML1-EVI-1
  • MDS1
  • MDS1-EVI1
  • PRDM3
  • D630039M04Rik
  • Evi-1
  • Evi1
  • Jbo
  • Mds
  • Mds1
  • Mds1-Evi1
  • Prdm3
  • Znfpr1b1
  • AML1
  • AMLCR1
  • CBFA2
  • EVI-1
  • PEBP2aB
  • MDS1 and EVI1 complex locus
  • runt-related transcription factor 1
  • mecom
  • MECOM
  • LOC100343228
  • Mecom
  • RUNX1
Epitope
AA 80-109, Middle Region
29
17
17
14
9
5
4
4
4
3
3
2
2
2
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
105
33
9
4
4
3
3
2
1
1
1
Host
Rabbit
71
31
15
Clonality
Polyclonal
Conjugate
Un-conjugated
6
6
6
6
6
6
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
104
65
11
5
3
2
1
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen KLH conjugated synthetic peptide between 80-109 amino acids from the Central region of human MDS1 Genename: MECOM
Isotype Ig
Specificity This antibody recognizes Human and Mouse MDS1 (Center).
Purification Protein A column, followed by peptide affinity purification
Alternative Name MDS1 (MECOM Antibody Abstract)
Background MDS1 is located at 3q26 170-400 kb upstream (telomeric) of EVI1 in the chromosomal region in which some of the breakpoints 5' of EVI1 have been mapped. MDS1 has been identified as a single gene as well as a previously unreported exon (s) of EVI1. MDS1 exists in normal tissues both as a unique transcript and as a normal fusion transcript with EVI1, with an additional 188 codons at the 5' end of the previously reported EVI1 open reading frame. In cells with translocation t (3,21), additional fusion transcripts are AML1-MDS1 and AML1-MDS1-EVI1. EVI1 and MDS1 are involved in leukemia associated with chromosomal translocation breakpoints in the region between these genes.Synonyms: Myelodysplasia syndrome 1, Myelodysplasia syndrome-associated protein 1
Molecular Weight 18696 Da
Gene ID 2122
NCBI Accession NP_004982
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-MDS1 and EVI1 Complex Locus (MECOM) (AA 80-109), (Middle Region) antibody (ABIN953364) Western blot analysis of MDS1 Antibody (Center) in mouse NIH-3T3 cell line lysates (3...
Background publications Goyama, Kurokawa: "Evi-1 as a critical regulator of leukemic cells." in: International journal of hematology, Vol. 91, Issue 5, pp. 753-7, 2010 (PubMed).

Gómez-Benito, Conchillo, García, Vázquez, Maicas, Vicente, Cristobal, Marcotegui, García-Ortí, Bandrés, Calasanz, Alonso, Odero: "EVI1 controls proliferation in acute myeloid leukaemia through modulation of miR-1-2." in: British journal of cancer, Vol. 103, Issue 8, pp. 1292-6, 2010 (PubMed).

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