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Mediator Complex Subunit 6 (MED6) (AA 134-164), (Middle Region) antibody

Details for Product No. ABIN953376
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Antigen
Synonyms NY-REN-28, wu:fa14c11, zgc:86933, 1500012F11Rik, AU019660, AV213303
Epitope
AA 134-164, Middle Region
(8), (8), (8), (7), (5), (2), (2), (1), (1), (1)
Reactivity
Human
(35), (5), (4), (2), (2), (2)
Host
Rabbit
(28), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
ELISA, Western Blotting (WB)
(32), (21), (4), (2), (2)
Pubmed 5 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN953376
357.50 $
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Immunogen KLH conjugated synthetic peptide between 134-164 amino acids from the Central region of human MED6
Specificity This antibody recognizes Human MED6 (Center).
Purification Protein A column, followed by peptide affinity purification
Alternative Name MED6
Background Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Alternate names: ARC33, Activator-recruited cofactor 33 kDa component, Mediator complex 6, Mediator of RNA polymerase II transcription subunit 6, Renal carcinoma antigen NY-REN-28
Molecular Weight 28425 Da
Gene ID 10001
NCBI Accession NP_005457
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Sato, Tomomori-Sato, Banks et al.: "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex." in: The Journal of biological chemistry, Vol. 278, Issue 50, pp. 49671-4, 2003 (PubMed).

Tomomori-Sato, Sato, Parmely et al.: "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2." in: The Journal of biological chemistry, Vol. 279, Issue 7, pp. 5846-51, 2004 (PubMed).

Yang, DeBeaumont, Zhou et al.: "The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 8, pp. 2339-44, 2004 (PubMed).

Sato, Tomomori-Sato, Parmely et al.: "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology." in: Molecular cell, Vol. 14, Issue 5, pp. 685-91, 2004 (PubMed).

Pavri, Lewis, Kim et al.: "PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator." in: Molecular cell, Vol. 18, Issue 1, pp. 83-96, 2005 (PubMed).

Validation Images
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