NEDD4-2 antibody (Middle Region)
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- Target See all NEDD4-2 (NEDD4L) Antibodies
- NEDD4-2 (NEDD4L) (E3 ubiquitin-protein ligase NEDD4-like (NEDD4L))
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Binding Specificity
- AA 575-604, Middle Region
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This NEDD4-2 antibody is un-conjugated
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Specificity
- This antibody recognizes Human and Mouse NEDD4L (Center).
- Purification
- Protein A column, followed by peptide affinity purification
- Immunogen
- KLH conjugated synthetic peptide between 575-604 amino acids from the Central region of human NEDD4L
- Isotype
- Ig Fraction
- Top Product
- Discover our top product NEDD4L Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.25 mg/mL
- Buffer
- PBS containing 0.09 % (W/V) Sodium Azide as preservative
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- NEDD4-2 (NEDD4L) (E3 ubiquitin-protein ligase NEDD4-like (NEDD4L))
- Alternative Name
- NEDD4L (NEDD4L Products)
- Synonyms
- NEDD4-2 antibody, NEDD4.2 antibody, RSP5 antibody, hNEDD4-2 antibody, nedd4 antibody, nedd4-2 antibody, NEDD4 antibody, Nedd4-2 antibody, 1300012C07Rik antibody, Nedd4b antibody, neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase antibody, NEDD4L antibody, neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase S homeolog antibody, neural precursor cell expressed, developmentally down-regulated gene 4-like antibody, NEDD4L antibody, LOC776799 antibody, nedd4l.S antibody, Nedd4l antibody
- Background
- E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK.Synonyms: KIAA0439, NEDD4.2, NEDL3, Nedd4-2
- Molecular Weight
- 111932 Da
- Gene ID
- 23327
- NCBI Accession
- NP_001138436
- Pathways
- Negative Regulation of Transporter Activity
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