NMDA Receptor 2A (AA 1064-1092), (Middle Region) antibody

Details for Product No. ABIN953720
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Antigen
Epitope
AA 1064-1092, Middle Region
(3), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(7), (7), (6), (1), (1), (1)
Host
Rabbit
(7), (2), (1)
Clonality
Polyclonal
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB)
(9), (4), (4), (1), (1), (1), (1), (1)
Pubmed 5 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN953720
357.50 $
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Immunogen KLH conjugated synthetic peptide between 1064-1092 amino acids from the Central region of Human NMDA Receptor 2A Genename: GRIN2A
Specificity This antibody recognizes Human and Mouse NMDA Receptor 2A (Center).
Purification Protein A column, followed by peptide affinity purification
Background N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alternate names: GRIN2A, Glutamate [NMDA] Receptor subunit epsilon-1, NMDAR2A, NR2A
Molecular Weight 165283 Da
Gene ID 2903
NCBI Accession NP_000824
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Saus, Brunet, Armengol et al.: "Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients." in: Journal of psychiatric research, Vol. 44, Issue 14, pp. 971-8, 2010 (PubMed).

King, Eugenin, Hazleton et al.: "Mechanisms of HIV-tat-induced phosphorylation of N-methyl-D-aspartate receptor subunit 2A in human primary neurons: implications for neuroAIDS pathogenesis." in: The American journal of pathology, Vol. 176, Issue 6, pp. 2819-30, 2010 (PubMed).

Pinheiro, Bulik, Thornton et al.: "Association study of 182 candidate genes in anorexia nervosa." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 153B, Issue 5, pp. 1070-80, 2010 (PubMed).

Shimada, Miyagawa, Kawashima et al.: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, 2010 (PubMed).

Endele, Rosenberger, Geider et al.: "Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes." in: Nature genetics, Vol. 42, Issue 11, pp. 1021-6, 2010 (PubMed).

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