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TLE1 antibody (Middle Region)
TLE1
Reactivity: Human
WB, EIA
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-TLE1 Antibody
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Target
See all TLE1 Antibodies
TLE1
(Transducin-Like Enhancer of Split 1 (E(sp1) Homolog, Drosophila) (TLE1))
Binding Specificity
All epitopes for TLE1 antibodies
AA 206-236, Middle Region
Reactivity
All reactivities for TLE1 antibodies
Human
Host
All hosts for TLE1 antibodies
Rabbit
Clonality
All clonalities for TLE1 antibodies
Polyclonal
Conjugate
All conjugates for TLE1 antibodies
This TLE1 antibody is un-conjugated
Application
All applications for TLE1 antibodies
Western Blotting (WB), Enzyme Immunoassay (EIA)
Specificity
This antibody detects TLE1 (Center).
Cross-Reactivity (Details)
Species reactivity (tested):Human
Purification
Protein A column followed by peptide affinity purification
Immunogen
KLH conjugated synthetic peptide between 206~236 amino acids from the Central region of human TLE1
Isotype
Ig Fraction
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
0.25 mg/mL
Buffer
PBS with 0.09 % (W/V) sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
Target Details for TLE1
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Target
TLE1
(Transducin-Like Enhancer of Split 1 (E(sp1) Homolog, Drosophila) (TLE1))
Alternative Name
TLE1 (TLE1 Products )
Synonyms
ESG antibody, ESG1 antibody, GRG1 antibody, C230057C06Rik antibody, Estm14 antibody, Grg1 antibody, Tle4l antibody, TLE1 antibody, transducin like enhancer of split 1 antibody, transducin-like enhancer protein 1 antibody, transducin-like enhancer of split 1 antibody, transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) antibody, TLE1 antibody, Smp_150080 antibody, Tle1 antibody, LOC100354911 antibody, LOC100524475 antibody, LOC100061341 antibody
Background
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.Synonyms: ESG1, Enhancer of split groucho-like protein 1, Transducin-like enhancer protein 1
Gene ID
7088
NCBI Accession
NP_005068
Pathways
WNT Signaling , SARS-CoV-2 Protein Interactome
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