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FKBP8 antibody (Internal Region)

FKBP8 Reactivity: Human, Mouse, Rat WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN964647
  • Target See all FKBP8 Antibodies
    FKBP8 (FK506 Binding Protein 8, 38kDa (FKBP8))
    Binding Specificity
    • 15
    • 8
    • 7
    • 6
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 49
    • 34
    • 25
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Human, Mouse, Rat
    Host
    • 60
    • 5
    • 1
    Rabbit
    Clonality
    • 61
    • 4
    Polyclonal
    Conjugate
    • 29
    • 7
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This FKBP8 antibody is un-conjugated
    Application
    • 53
    • 25
    • 14
    • 14
    • 11
    • 6
    • 5
    • 4
    • 4
    • 4
    • 1
    • 1
    Western Blotting (WB), ELISA
    Specificity
    This product was protein A purified from monospecific antiserum by immunoaffinity chromatography using protein A coupled to agarose beads.  This antibody is specific for human FKBP8 protein.  A BLAST analysis was used to suggest partial cross-reactivity with FKBP8 from mouse and rat sources based on ~93% homology with the immunizing sequence.  Cross-reactivity with FKBP8 from other sources has not been determined.
    Cross-Reactivity
    Mouse (Murine), Rat (Rattus)
    Characteristics
    FKBP8 (also known as FK506-binding protein 38) is a member of the immunophilin family that has been implicated to play an important role in apoptosis through its involvement in the mechanism that targets Bcl-2 and Bcl-xL to the outer mitochondrial membrane (OMM). Suppression of endogenous FKBP8 by RNAi or transfection of a mutant FKBP8 missing the transmembrane domain necessary for mitochondrial insertion, resulted in the translocation of Bcl-2 and Bcl-xL from the OMM to the cytosol. It has also been suggested that FKBP8 may play
    Purification
    affinity purified
    Sterility
    Sterile filtered
    Immunogen
    This protein A purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region of human FKBP8 protein.
    Immunogen Type: Peptide
    Isotype
    IgG
    Top Product
    Discover our top product FKBP8 Primary Antibody
  • Application Notes
    This protein A purified antibody has been tested for use in ELISA and western blotting.  Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 64 kDa in size corresponding to FKBP8 by western blotting in the appropriate cell lysate or extract.
    Comment

    Gene Name: FKBP8

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is three (3) months from date of opening.
    Expiry Date
    3 months
  • Target
    FKBP8 (FK506 Binding Protein 8, 38kDa (FKBP8))
    Alternative Name
    FKBP8 (FKBP8 Products)
    Synonyms
    FKBP8 antibody, fkbp8 antibody, 38kDa antibody, FKBP-38 antibody, FKBP-8 antibody, Fkbp38 antibody, zgc:77672 antibody, FKBP38 antibody, FKBPr38 antibody, FK506 binding protein 8 antibody, FK506 binding protein 8 L homeolog antibody, FKBP8 antibody, fkbp8 antibody, Fkbp8 antibody, fkbp8.L antibody
    Background
    FKBP8 (also known as FK506-binding protein 38) is a member of the immunophilin family that has been implicated to play an important role in apoptosis through its involvement in the mechanism that targets Bcl-2 and Bcl-xL to the outer mitochondrial membrane (OMM). Suppression of endogenous FKBP8 by RNAi or transfection of a mutant FKBP8 missing the transmembrane domain necessary for mitochondrial insertion, resulted in the translocation of Bcl-2 and Bcl-xL from the OMM to the cytosol. It has also been suggested that FKBP8 may play
    Synonyms: 38 kDa FK 506 binding protein homolog antibody, 38kDa antibody, FK506 binding protein 8 antibody, FKBP 38 antibody
    Gene ID
    23770, 52630440
    UniProt
    Q14318
    Pathways
    Autophagy
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