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Details for Product No. ABIN965581

Amyloid beta (A4) Precursor Protein (APP) (N-Term), (AA 18-32) antibody

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Antigen
Synonyms
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, APP, APP-like, APPL, Abeta, BcDNA:GH04413, CG7727, Dmel\\CG7727, EG:65F1.5, appl, Abpp, Adap, Ag, Cvap, E030013M08Rik, betaApp, app, wu:fj34d10 ... show more
Epitope
»Alternatives N-Term, AA 18-32
Reactivity
»Alternatives Human, Rat (Rattus)
Host
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 4 references available
Catalog no. ABIN965581
Quantity 100 µg
Price
316.25 $   Plus shipping costs $45.00
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Availability Will be delivered in 5 to 7 Business Days
Immunogen A synthetic peptide corresponding to a sequence at the N-terminal of human APP (18-32 aa), identical to the related mouse and rat sequence.
Alternative Name APP
Background Amyloid precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. Its primary function is not known, though it has been implicated as a regulator of synapse formation, neural plasticity and iron export. APP is best known and most commonly studied as the precursor molecule whose proteolysis generates beta amyloid (A), a 39- to 42-amino acid peptide whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients. APP undergoes posttranslational proteolytic processing by alpha-, beta-, and gamma-secretases. Alpha-secretase generates soluble amyloid protein, while beta- and gamma-secretases generate APP components with amyloidogenic features. These 2 processing pathways are mutually exclusive.
Research Area Signaling
Restrictions For Research Use only
Reconstitution 0.2ml of distilled water will yield a concentration of 500µg/ml.
Buffer Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
Preservative Thimerosal (Merthiolate), Sodium azide
Storage -20 °C
Product cited in: Turner, OConnor, Tate et al.: "Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory." in: Progress in neurobiology, Vol. 70, Issue 1, pp. 1-32, 2003 (PubMed).

Wang, Ha: "The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain." in: Molecular cell, Vol. 15, Issue 3, pp. 343-53, 2004 (PubMed).

Priller, Bauer, Mitteregger et al.: "Synapse formation and function is modulated by the amyloid precursor protein." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 26, Issue 27, pp. 7212-21, 2006 (PubMed).

Duce, Tsatsanis, Cater et al.: "Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease." in: Cell, Vol. 142, Issue 6, pp. 857-67, 2010 (PubMed).

Alternatives for antigen "Amyloid beta (A4) Precursor Protein (APP)", type "Antibodies"
Hosts (381), (110), (42), (5), (1)
Reactivities (489), (231), (226), (106), (98), (95), (92), (17), (14), (7), (5), (5), (4), (4), (3), (3), (3), (3), (2), (2), (1), (1), (1)
Applications (374), (206), (129), (98), (90), (37), (36), (15), (14), (11), (7), (7), (4), (2), (2), (1), (1), (1), (1)
Conjugates (14), (11), (10), (9), (9), (9), (9), (9), (9), (9), (9), (1), (1)
Epitopes (63), (50), (30), (30), (19), (13), (13), (10), (9), (7), (6), (6), (5), (5), (5), (4), (4), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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