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V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog (KIT) antibody

Antigen

V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog (KIT)
Synonyms PBT, SCFR, C-Kit, CD117, W, Bs, Fdc, Ssm, SCO1, SCO5, SOW3, c-KIT, Tr-kit, Gsfsco1, Gsfsco5, Gsfsow3, c-kit, kit-A, XKrk1, KIT, MGF, LOC100221238, C-KIT
Clonality Monoclonal
Host
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives ELISA
3 references available
Catalog no. ABIN965728
Quantity 0.1ml
Price 426.25 $   Plus shipping costs $45.00
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Additional Information
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Alternative name C-Kit
Gene ID 3815
Isotype IgG1
Description C-kit (CD117,145kDa) functions as a tyrosine kinase receptor which becomes activated upon binding of its ligand SCF (stem-cell factor), the C-kit gene encodes the human homolog of the proto-oncogene ckit. which was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT is a type 3 transmembrane receptor for MGF (mast cell growth factor). Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism.
Specificity Ni-NTA purified truncated recombinant C-kit expressed in E. Coli strain BL21 (DE3)

Application Details
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Application Notes Dilution ELISA: Propose dilution 1: 10,000
Determining optimal working dilutions by titration test.
Purification Antibodies are purified by protein A affinity chromatography
Storage Store at -20° C.
Research Area Proliferation Markers
Restrictions For Research Use only

Publications
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Product Tong, Liu, Zhang et al.: "Expression of c-kit messenger ribonucleic acid and c-kit protein in sigmoid colon of patients with slow transit constipation." in: International journal of colorectal disease, Vol. 20, Issue 4, pp. 363-7, 2005 (PubMed).

Nakai, Nonomura, Oka et al.: "KIT (c-kit oncogene product) pathway is constitutively activated in human testicular germ cell tumors." in: Biochemical and biophysical research communications, Vol. 337, Issue 1, pp. 289-96, 2005 (PubMed).

Mojica, Saxena, Starostik et al.: "CD117+ small cell lung cancer lacks the asp 816-->val point mutation in exon 17." in: Histopathology, Vol. 47, Issue 5, pp. 517-22, 2005 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog (KIT)", type "Antibodies"
Hosts Rabbit (109), Mouse (62), Rat (45)
Reactivities Human (158), Mouse (Murine) (90), Rat (Rattus) (45), Cow (Bovine) (29), Dog (Canine) (21), Pig (Porcine) (16), Horse (Equine) (15), Primate (12), Chicken (8), Monkey (3)
Applications Flow Cytometry (FACS) (88), Western Blotting (WB) (53), Immunofluorescence (IF) (40), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (40), Immunohistochemistry (IHC) (32), ELISA (31), Immunohistochemistry (Frozen Sections) (IHC (fro)) (23), Immunoprecipitation (IP) (18), Immunocytochemistry (ICC) (17), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (4), Functional Studies (Func) (2), Dot Blot (DB) (1), Neutralization (Neut) (1)
Conjugates PE (20), FITC (14), Biotin (12), APC (5), Alexa Fluor 350 (5), Alexa Fluor 488 (5), Alexa Fluor 555 (5), Alexa Fluor 647 (5), PE,Cy5.5 (5), APC,Cy7 (2), Cy5 (2), SPRD (2), PE-Cy5 (1), PerCP (1), PerCP-Cy5.5 (1), RPE (1)
Epitopes pTyr721 (12), pTyr936 (10), pSer741 (5), pTyr703 (5), C-Term (4), Extracellular Domain (4), pSer721 (4), Tyr721 (3), Tyr936 (3), pTyr719 (2), N-Term (1), pSer27 (1), pSer392 (1), pSer740 (1), pY721 (1), pY936 (1)