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Capsid Protein VP1 (N-Term) antibody

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Immunohistochemistry (IHC)
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of Norovirus Capsid protein VP1
Background Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate the genomic RNA and VP2 proteins. Capsid protein VP1 attaches virion to target cells by binding histo-blood group antigens present on gastroduodenal epithelial cells. Soluble capsid protein may play a role in viral immunoevasion. Capsid protein VP1 binds to histoblood group antigens at surface of target cells. The shell domain (S domain) contains elements essential for the formation of the icosahedron. The Protruding domain (P domain) is divided into subdomains P1 and P2. P domain interacts in dimeric contacts that increase the stability of the capsid and form the protrusions on the virion. An hypervariable region in P2 is thought to play an important role in receptor binding and immune reactivity.
Restrictions For Research Use only
Product cited in: Tan, Meller, Jiang: "C-terminal arginine cluster is essential for receptor binding of norovirus capsid protein." in: Journal of virology, Vol. 80, Issue 15, pp. 7322-31, 2006

Bertolotti-Ciarlet, Crawford, Hutson, Estes: "The 3' end of Norwalk virus mRNA contains determinants that regulate the expression and stability of the viral capsid protein VP1: a novel function for the VP2 protein." in: Journal of virology, Vol. 77, Issue 21, pp. 11603-15, 2003

Huang, Farkas, Marionneau, Zhong, Ruvoën-Clouet, Morrow, Altaye, Pickering, Newburg, LePendu, Jiang: "Noroviruses bind to human ABO, Lewis, and secretor histo-blood group antigens: identification of 4 distinct strain-specific patterns." in: The Journal of infectious diseases, Vol. 188, Issue 1, pp. 19-31, 2003

Prasad, Hardy, Dokland, Bella, Rossmann, Estes: "X-ray crystallographic structure of the Norwalk virus capsid." in: Science (New York, N.Y.), Vol. 286, Issue 5438, pp. 287-90, 1999

White, Hardy, Estes: "Biochemical characterization of a smaller form of recombinant Norwalk virus capsids assembled in insect cells." in: Journal of virology, Vol. 71, Issue 10, pp. 8066-72, 1997

White, Ball, Hardy, Tanaka, Kitamoto, Estes: "Attachment and entry of recombinant Norwalk virus capsids to cultured human and animal cell lines." in: Journal of virology, Vol. 70, Issue 10, pp. 6589-97, 1996

Hardy, White, Ball, Estes: "Specific proteolytic cleavage of recombinant Norwalk virus capsid protein." in: Journal of virology, Vol. 69, Issue 3, pp. 1693-8, 1995

Jiang, Wang, Wang, Estes: "Sequence and genomic organization of Norwalk virus." in: Virology, Vol. 195, Issue 1, pp. 51-61, 1993