Capsid Protein Vp1 (AA 228-781) antibody (FITC)

Catalog No. ABIN7162678

Product Details

Target: Capsid Protein Vp1

Binding Specificity: AA 228-781

Reactivity: Human Parvovirus B19 (HPV B19)

Host: Rabbit

Clonality: Polyclonal

Conjugate: FITC

Application: Please inquire

Cross-Reactivity: Human Parvovirus B19 (HPV B19)

Purification: >95%, Protein G purified

Immunogen: Recombinant Human parvovirus B19 Capsid protein VP2 protein (228-781AA)

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details

Target: Capsid Protein Vp1

Target Type: Viral Protein

Background:

Background: Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of two size variants of the capsid proteins, VP1 and VP2, which differ by the presence of an N-terminal extension in the minor protein VP1. The capsid encapsulates the genomic ssDNA. Capsid proteins are responsible for the attachment to host cell receptors, such as the glycosphingolipid globoside or the integrin heterodimer ITGAV/ITGB1. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell. Intracytoplasmic transport involves microtubules and interaction between capsid proteins and host dynein. Exposure of nuclear localization signal probably allows nuclear import of capsids (By similarity).

Aliases: Minor capsid protein VP1 antibody, EC 3.1.1.4 antibody, Coat protein VP1 antibody

UniProt: P07299