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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Chromobox Homolog 1 (CBX1) antibody
|Synonyms||CBX, M31, MOD1, p25beta, HP1-BETA, HP1Hsbeta, HP1Hs-beta|
Alternatives Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), ELISA
|3 references available|
|Price||426.25 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 5 to 7 Business Days|
|Immunogen||Purified recombinant fragment of human CBX1 expressed in E. Coli.|
|Description||This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified.|
Western Bloting: 1/500 - 1/2000.
Immunofluorescence: 1/200 - 1/1000.
Flow cytometry: 1/200 - 1/400.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
|Preservative||0.03% sodium azide.|
|Storage||Store at 4°C, for long term storage, store at -20°C.|
|Restrictions||For Research Use only|
Hughes-Davies, Huntsman, Ruas et al.: "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer." in: Cell, Vol. 115, Issue 5, pp. 523-35, 2003 (PubMed).
Stelzl, Worm, Lalowski et al.: "A human protein-protein interaction network: a resource for annotating the proteome." in: Cell, Vol. 122, Issue 6, pp. 957-68, 2005 (PubMed).
Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).