CDK1 antibody (Cyclin-Dependent Kinase 1)

Details for Product anti-CDK1 Antibody No. ABIN965826, Supplier: Log in to see
Antigen
  • 5363
  • CDC2
  • CDCDm
  • CDK1
  • CDK1/CDC2
  • CG5363
  • Cdc2
  • Cdk-1
  • Cdk1
  • Dcdc2
  • Dm cdc2
  • DmCdc2
  • DmCdk1
  • Dmcdc2
  • Dmel\\CG5363
  • cdc
  • cdc2Dm
  • cdk1
  • dCdk1
  • group 4
  • l(2)31Eh
  • CDC28A
  • P34CDC2
  • Cdc2a
  • p34
  • cdc2
  • wu:fc30e01
  • zgc:92032
  • PSTAIR
  • cdc-2
  • cdc2-a
  • cdc28a
  • cdc2x1.1
  • p34cdc2
  • xcdc2
  • CDC2A
  • CDC2AAT
  • CDK2
  • CDKA1
  • CDKA;1
  • CYCLIN-DEPENDENT KINASE A;1
  • cell division control 2
  • POL3
  • pold
  • cyclin-dependent kinase 1
  • cell division control protein2 homolog
  • CG5363 gene product from transcript CG5363-RA
  • cyclin-dependent kinase A-1
  • cyclin-dependent kinase-like 1
  • polymerase (DNA directed), delta 1, catalytic subunit
  • Protein CDK-1
  • PtrCDKA-1
  • cdc2
  • CDK1
  • Cdk1
  • cdk1
  • cdk1-a
  • CDC2
  • LOC100346649
  • pold1
  • cdk-1
Alternatives
anti-Human CDK1 antibody for Cytometry by Time of Flight
Reactivity
Human
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375
328
68
60
55
46
29
21
19
19
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18
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15
12
12
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11
8
8
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4
2
2
2
2
1
1
1
1
1
1
1
1
Host
Mouse
513
246
Clonality (Clone)
Monoclonal ()
Conjugate
This CDK1 antibody is un-conjugated
31
27
26
20
16
16
9
9
5
5
5
5
5
5
5
5
5
4
4
4
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4
4
4
4
4
3
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2
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
638
287
174
143
121
88
73
66
51
48
17
8
7
7
6
6
2
2
1
1
1
1
1
Options
Supplier
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Immunogen Purified recombinant fragment of CDC2 expressed in E. Coli.
Clone 8C5A6
Isotype IgG1
Purification Ascitic fluid
Alternative Name CDC2 (CDK1 Antibody Abstract)
Background The cell division control protein cdc2, also known as cyclin-dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S-phase and mitosis. Cdc2 exists as a complex with both cyclin A and cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2deltaT is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration.
Synonyms: CDC2, CDC28A, P34CDC2, MGC111195, DKFZp686L20222, CDK1
Molecular Weight 34kDa
Gene ID 983
Research Area Cell Cycle
Pathways Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Toll-Like Receptors Cascades, Synthesis of DNA
Application Notes Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Meyer, Merkel, Brückl, Schellerer, Schildberg, Campean, Hohenberger, Croner: "Cdc2 as prognostic marker in stage UICC II colon carcinomas." in: European journal of cancer (Oxford, England : 1990), Vol. 45, Issue 8, pp. 1466-73, 2009 (PubMed).

Tang, Wu, Guo, Hansen, Perry, Freel, Nutt, Jackson, Kornbluth: "Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition." in: Molecular biology of the cell, Vol. 19, Issue 8, pp. 3536-43, 2008 (PubMed).