CHEK2 antibody (Checkpoint Kinase 2)

Details for Product anti-CHEK2 Antibody No. ABIN965891, Supplier: Log in to see
Antigen
  • CDS1
  • CHK2
  • HuCds1
  • LFS2
  • PP1425
  • RAD53
  • hCds1
  • fa66f08
  • wu:fa66f08
  • zgc:55865
  • Cds1
  • HUCDS1
  • Rad53
  • Chk2
  • CHK-2
  • checkpoint kinase 2
  • CHK2 checkpoint homolog (S. pombe)
  • serine/threonine-protein kinase chk2
  • blue sensitive cone opsin
  • CHEK2
  • chek2
  • Chek2
  • MCYG_07308
  • LOC396525
Alternatives
anti-Human CHEK2 antibody for Immunofluorescence (fixed cells)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
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8
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2
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1
1
1
Host
Rabbit
340
132
8
1
1
Clonality
Polyclonal
Conjugate
This CHEK2 antibody is un-conjugated
9
8
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7
5
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5
5
5
5
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5
4
2
2
2
2
2
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2
1
1
Application
Immunohistochemistry (IHC)
386
120
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84
66
44
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26
6
6
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2
1
1
Options
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Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human Chk2 around the phosphorylation site of threonine 68.
Specificity Chk2 (Ab-68) antibody detects endogenous levels of total Chk2 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Alternative Name CHK2 (CHEK2 Antibody Abstract)
Pathways p53 Signaling, Apoptosis, Cell Division Cycle
Application Notes WB: 1:500~1:1000
IHC: 1:50~1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Bhoumik, Takahashi, Breitweiser, Shiloh, Jones, Ronai: "ATM-dependent phosphorylation of ATF2 is required for the DNA damage response." in: Molecular cell, Vol. 18, Issue 5, pp. 577-87, 2005 (PubMed).

Gorgoulis, Vassiliou, Karakaidos, Zacharatos, Kotsinas, Liloglou, Venere, Ditullio, Kastrinakis, Levy, Kletsas, Yoneta, Herlyn, Kittas, Halazonetis: "Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions." in: Nature, Vol. 434, Issue 7035, pp. 907-13, 2005 (PubMed).

Jin, Kurosu, Yamaguchi, Arai, Miura: "Hematopoietic cytokines enhance Chk1-dependent G2/M checkpoint activation by etoposide through the Akt/GSK3 pathway to inhibit apoptosis." in: Oncogene, Vol. 24, Issue 12, pp. 1973-81, 2005 (PubMed).

Li, Stern: "Regulation of CHK2 by DNA-dependent protein kinase." in: The Journal of biological chemistry, Vol. 280, Issue 12, pp. 12041-50, 2005 (PubMed).

Background publications Falck, Coates, Jackson: "Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage." in: Nature, Vol. 434, Issue 7033, pp. 605-11, 2005 (PubMed).