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DISC1 antibody (Disrupted in Schizophrenia 1) (C-Term)

Details for Product anti-DISC1 Antibody No. ABIN965998, Supplier: Log in to see
Antigen
  • C1orf136
  • DISC1
  • SCZD9
Epitope
C-Term
52
48
19
18
17
14
6
5
5
5
4
2
2
2
1
1
1
1
1
1
Reactivity
Human
155
72
48
Host
Rabbit
155
15
14
3
Clonality
Polyclonal
Conjugate
This DISC1 antibody is un-conjugated
9
8
7
4
4
3
3
3
3
3
3
2
2
2
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC)
143
78
74
57
19
15
14
12
7
5
1
Supplier
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human DISC1(Disrupted in schizophrenia 1 protein)
Purification Purified by antigen-specific affinity chromatography.
Alternative Name DISC1 (Disrupted in schizophrenia 1 protein) (DISC1 Antibody Abstract)
Background DISC1 (Disrupted in schizophrenia 1 protein) is a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. DISC1 is involved in neurite outgrowth and cortical development through its interaction with other proteins. DISC1 interacts with tubulin alpha, ACTN2, ANKHD1, ATF4, ATF5, CEP63, EIF3S3, MAP1A, NDEL1, PAFAH1B1, RANBP9, SPTBN4, SYNE1 and TRAF3IP1. The interaction with microtubules may be mediated in part by TRAF3IP1. A chromosomal aberration involving DISC1 segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Translocation t(1,11)(q42.1,q14.3). The truncated DISC1 protein produced by this translocation is unable to interact with ATF4, ATF5 and NDEL1.
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Taylor, Devon, Millar, Porteous: "Evolutionary constraints on the Disrupted in Schizophrenia locus." in: Genomics, Vol. 81, Issue 1, pp. 67-77, 2003 (PubMed).

Morris, Kandpal, Ma, Austin: "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation." in: Human molecular genetics, Vol. 12, Issue 13, pp. 1591-608, 2003 (PubMed).

Ozeki, Tomoda, Kleiderlein, Kamiya, Bord, Fujii, Okawa, Yamada, Hatten, Snyder, Ross, Sawa: "Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 1, pp. 289-94, 2003 (PubMed).

Millar, Wilson-Annan, Anderson, Christie, Taylor, Semple, Devon, St Clair, Muir, Blackwood, Porteous: "Disruption of two novel genes by a translocation co-segregating with schizophrenia." in: Human molecular genetics, Vol. 9, Issue 9, pp. 1415-23, 2000 (PubMed).

Seki, Ohira, Nagase, Ishikawa, Miyajima, Nakajima, Nomura, Ohara: "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 4, Issue 5, pp. 345-9, 1998 (PubMed).