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Fanconi Anemia Complementation Group G (FANCG) (C-Term) antibody

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Antigen
  • AU041407
  • FAG
  • xFANCG
  • Xrcc9
  • XRCC9
Epitope
C-Term
38
21
16
9
8
7
5
2
1
1
1
1
1
1
Reactivity
Human
125
35
32
3
3
2
2
1
Host
Rabbit
87
19
19
Clonality
Polyclonal
Conjugate
Un-conjugated
6
6
6
4
4
4
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (IHC)
92
61
30
22
19
12
8
5
5
3
2
Supplier
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human FANCG (Fanconi anemia group G protein)
Alternative Name FANCG (FANCG Antibody Abstract)
Background DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. FANCG may be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. FANCG is a andidate tumor suppressor gene. FANCG belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. The complex is not found in FA patients. The major form is nuclear. The minor form is cytoplasmic. Highly expressed in testis and thymus. Found in lymphoblasts. Defects in FANCG are a cause of Fanconi anemia (FA)
Synonym: XRCC9 (DNA repair protein XRCC9)
Research Area Chromatin and Nuclear Signaling, DNA/RNA
Restrictions For Research Use only
Background publications Sjöblom, Jones, Wood, Parsons, Lin, Barber, Mandelker, Leary, Ptak, Silliman, Szabo, Buckhaults, Farrell, Meeh, Markowitz, Willis, Dawson, Willson, Gazdar, Hartigan, Wu, Liu, Parmigiani, Park et al.: "The consensus coding sequences of human breast and colorectal cancers. ..." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).

Meetei, Sechi, Wallisch, Yang, Young, Joenje, Hoatlin, Wang: "A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome." in: Molecular and cellular biology, Vol. 23, Issue 10, pp. 3417-26, 2003 (PubMed).

Liu, Lamerdin, Tucker, Zhou, Walter, Albala, Busch, Thompson: "The human XRCC9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40 cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 17, pp. 9232-7, 1997 (PubMed).

Product cited in: Meetei, Levitus, Xue, Medhurst, Zwaan, Ling, Rooimans, Bier, Hoatlin, Pals, de Winter, Wang, Joenje: "X-linked inheritance of Fanconi anemia complementation group B." in: Nature genetics, Vol. 36, Issue 11, pp. 1219-24, 2004 (PubMed).

Demuth, Wlodarski, Tipping, Morgan, de Winter, Thiel, Gräsl, Schindler, DAndrea, Altay, Kayserili, Zatterale, Kunze, Ebell, Mathew, Joenje, Sperling, Digweed: "Spectrum of mutations in the Fanconi anaemia group G gene, FANCG/XRCC9." in: European journal of human genetics : EJHG, Vol. 8, Issue 11, pp. 861-8, 2000 (PubMed).

Garcia-Higuera, Kuang, Näf, Wasik, DAndrea: "Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex." in: Molecular and cellular biology, Vol. 19, Issue 7, pp. 4866-73, 1999 (PubMed).