FGF1
Reactivity: Human, Mouse, Rat
WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Host: Rabbit
Polyclonal
unconjugated
Restrictions
For Research Use only
Reconstitution
0.2ml of distilled water will yield a concentration of 500µg/ml.
Buffer
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
Preservative
Thimerosal (Merthiolate), Sodium azide
Storage
-20 °C
Le Beau, Espinosa, Neuman, Stock, Roulston, Larson, Keinanen, Westbrook: "Cytogenetic and molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 12, pp. 5484-8, (1993) (PubMed).
Mergia, Eddy, Abraham, Fiddes, Shows: "The genes for basic and acidic fibroblast growth factors are on different human chromosomes." in: Biochemical and biophysical research communications, Vol. 138, Issue 2, pp. 644-51, (1986) (PubMed).
Burgess, Mehlman, Marshak, Fraser, Maciag: "Structural evidence that endothelial cell growth factor beta is the precursor of both endothelial cell growth factor alpha and acidic fibroblast growth factor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, Issue 19, pp. 7216-20, (1986) (PubMed).
Fibroblast growth factor 1 (acidic), also known as FGF1/ECGF/HBGF1, is a human gene which is mapped to 5q311. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Additionally, Acidic fibroblast growth factor is derived from beta-endothelial cell growth factor (ECGFB) by posttranslational processing. Alpha-ECGF is also derived from ECGFB in the same manner.2, 3