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V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) antibody

Antigen

V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2)
Synonyms Neu, HER2, HER-2, c-neu, Erbb-2, c-erbB2, mKIAA3023, NEU, NGL, TKR1, CD340, HER-2/neu
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunohistochemistry (IHC)
5 references available
Catalog no. ABIN966277
Quantity 100ug  (100ug/100ul.)  (Variants)
Price 385.00 $   Plus shipping costs $45.00
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Alternative name HER2
Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human HER2 around the phosphorylation site of tyrosine 1221/1222 (N-L-YP-YP -W).
Specificity HER2 (Ab-1221/1222) antibody detects endogenous levels of total HER2 protein.

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Application Notes WB: 1:500~1:1000
IHC: 1:50~1:100.
Concentration 100ug/100ul.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative 0.02% Sodium Azide
Storage Store at -20°C/1 year.
Restrictions For Research Use only

Publications
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Product Ouyang, Huang, Chantry et al.: "Adjacent carboxyterminal tyrosine phosphorylation events identify functionally distinct ErbB2 receptor subsets: implications for molecular diagnostics." in: Experimental cell research, Vol. 241, Issue 2, pp. 467-75, 1998 (PubMed).

Ouyang, Gulliford, Epstein: "The duration of phorbol-inducible ErbB2 tyrosine dephosphorylation parallels that of receptor endocytosis rather than threonine-686 phosphorylation: implications for the physiological role of protein kinase C in growth factor receptor signalling." in: Carcinogenesis, Vol. 19, Issue 11, pp. 2013-9, 1998 (PubMed).

Klapper, Waterman, Sela et al.: "Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2." in: Cancer research, Vol. 60, Issue 13, pp. 3384-8, 2000 (PubMed).

Ren, Schaefer: "ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner." in: The Journal of biological chemistry, Vol. 277, Issue 41, pp. 38486-93, 2002 (PubMed).

Marone, Hess, Dankort et al.: "Memo mediates ErbB2-driven cell motility." in: Nature cell biology, Vol. 6, Issue 6, pp. 515-22, 2004 (PubMed).

Alternatives
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Alternatives for antigen "V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2)", type "Antibodies"
Hosts Rabbit (359), Mouse (151), Chicken (10), Rat (7), Sheep (4), Goat (1)
Reactivities Human (509), Mouse (Murine) (200), Rat (Rattus) (182), Dog (Canine) (80), Horse (Equine) (72), Cow (Bovine) (37), Pig (Porcine) (36), Chicken (19), Guinea Pig (18), Sheep (Ovine) (18), Monkey (5), Cat (Feline) (1)
Applications Western Blotting (WB) (288), Immunofluorescence (IF) (192), ELISA (156), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (138), Immunohistochemistry (IHC) (128), Immunoprecipitation (IP) (96), Flow Cytometry (FACS) (29), Dot Blot (DB) (27), Immunocytochemistry (ICC) (26), Immunohistochemistry (Fixed) (IHC (fx)) (23), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (23), Immunohistochemistry (Frozen Sections) (IHC (fro)) (15), Electrophoretic Mobility-Shift Assay (EMSA) (11), Immunoelectron Microscopy (IEM) (6), Enzyme Immunoassay (EIA) (5), Functional Studies (Func) (4), Cellular Assay (CA) (1), Dot Blot (Dot) (1), Immunoassay (IA) (1), Immunostaining (ISt) (1), Radioimmunoassay (RIA) (1)
Conjugates Biotin (21), FITC (7), Alexa Fluor 350 (6), Alexa Fluor 488 (6), Alexa Fluor 555 (6), Alexa Fluor 647 (6), Cy3 (6), Cy5 (6), Cy5.5 (6), Cy7 (6), Gold (6), HRP (6), PE (6), PE,Cy3 (6), PE,Cy5 (6), PE,Cy5.5 (6), PE,Cy7 (6)
Epitopes pTyr1248 (41), C-Term (38), pTyr877 (36), pTyr1112 (24), pTyr1221,pTyr1222 (19), Extracellular Domain (18), pTyr686 (18), Internal Region (11), Tyr1248 (9), AA 750-987 (6), Cytoplasmic Domain (6), pTyr1221, pTyr1222 (6), N-Term (5), pThr686 (5), pTyr1222,pTyr1221 (5), AA 153-433 (3), pSer1113 (3), pTyr1112,C-Term (3), pTyr1139 (3), AA 1240-1260 (2), AA 1243-1255 (2), Tyr1221,Tyr1222 (2), Tyr877 (2), pSer1051 (2), AA 1238-1255 (1), AA 1242-1255,C-Term (1), AA 146-195 (1), AA 23-419 (1), AA 23-652 (1), AA 860-880 (1), AA 968-1020 (1), C-Term,AA 1008-1038 (1), C-Term,AA 1035-1064 (1), C-Term,AA 1039-1069 (1), C-Term,AA 1069-1098 (1), C-Term,AA 1092-1121 (1), C-Term,AA 1097-1127 (1), C-Term,AA 1112-1142 (1), C-Term,AA 1125-1154 (1), C-Term,AA 1136-1166 (1), C-Term,AA 1153-1183 (1), C-Term,AA 1158-1188 (1), C-Term,AA 1182-1211 (1), Internal Region,AA 530-559 (1), Internal Region,AA 714-743 (1), Internal Region,AA 862-891 (1), Internal Region,AA 984-1013 (1), Internal Region,AA 985-1014 (1), Ser1112 (1), Ser877 (1), Tyr1196 (1), Tyr1221, Tyr1222 (1), Tyr1222 (1), pSer1050 (1), pSer1054 (1), pSer1083 (1), pSer1107 (1), pSer1114 (1), pSer1151 (1), pSer1174 (1), pSer728 (1), pSer998 (1), pSer999 (1), pThr1166 (1), pThr1168 (1), pThr1172 (1), pThr1221, pThr1222 (1), pThr701 (1), pTyr1005 (1), pTyr1127 (1), pTyr1129 (1), pTyr1140 (1), pTyr1196 (1), pTyr1197 (1), pTyr1221 (1), pTyr1222 (1), pTyr1223 (1)