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HER2 antibody (V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian))

Details for Product anti-ERBB2 Antibody No. ABIN966277, Supplier: Login to see New
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Antigen
Synonyms CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1, Erbb-2, Neu, c-erbB2, c-neu, mKIAA3023
Alternatives
Reactivity
Human
(1242), (415), (240), (25), (14), (4), (3), (3), (3), (3), (2), (2), (1), (1), (1)
Host
Rabbit
(986), (395), (21), (19), (5), (5)
Clonality
Polyclonal
Conjugate
This HER2 antibody is un-conjugated
(73), (62), (52), (45), (45), (41), (11), (9), (9), (8), (8), (8), (8), (8), (8), (2), (2), (1)
Application
Immunohistochemistry (IHC)
(668), (521), (335), (323), (243), (228), (142), (139), (93), (62), (24), (21), (17), (10), (6), (6), (5), (5), (3), (3), (2), (2), (1), (1), (1), (1)
Pubmed 5 references available
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Quantity 100 μg
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Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human HER2 around the phosphorylation site of tyrosine 1221/1222 (N-L-YP-YP -W).
Specificity HER2 (Ab-1221/1222) antibody detects endogenous levels of total HER2 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Alternative Name HER2 (ERBB2 Antibody Abstract)
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes WB: 1:500~1:1000
IHC: 1:50~1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Marone, Hess, Dankort et al.: "Memo mediates ErbB2-driven cell motility." in: Nature cell biology, Vol. 6, Issue 6, pp. 515-22, 2004 (PubMed).

Ren, Schaefer: "ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner." in: The Journal of biological chemistry, Vol. 277, Issue 41, pp. 38486-93, 2002 (PubMed).

Klapper, Waterman, Sela et al.: "Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2." in: Cancer research, Vol. 60, Issue 13, pp. 3384-8, 2000 (PubMed).

Ouyang, Gulliford, Epstein: "The duration of phorbol-inducible ErbB2 tyrosine dephosphorylation parallels that of receptor endocytosis rather than threonine-686 phosphorylation: implications for the physiological role of protein kinase C in growth factor receptor signalling." in: Carcinogenesis, Vol. 19, Issue 11, pp. 2013-9, 1998 (PubMed).

Ouyang, Huang, Chantry et al.: "Adjacent carboxyterminal tyrosine phosphorylation events identify functionally distinct ErbB2 receptor subsets: implications for molecular diagnostics." in: Experimental cell research, Vol. 241, Issue 2, pp. 467-75, 1998 (PubMed).

Catalog No. ABIN966277
$398.75
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