HTR2A antibody (C-Term)

Catalog No. ABIN966325

This Polyclonal antibody specifically detects HTR2A in WB and IHC (p). It exhibits reactivity toward Human, Rat and Mouse. It has been mentioned in 2+ publications

Quick Overview for HTR2A antibody (C-Term) (ABIN966325)

Target: HTR2A (5-Hydroxytryptamine (serotonin) Receptor 2A (HTR2A))

Reactivity: Human, Rat, Mouse

Host: Please inquire

Clonality: Polyclonal

Conjugate: This HTR2A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-HTR2A Antibody

Binding Specificity: AA 418-432, C-Term

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminal of human HTR2A (418-432 aa), different from the mouse sequence by one amino acid.

Application Details

Restrictions: For Research Use only

Handling

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4

Preservative: Thimerosal (Merthiolate), Sodium azide

Storage: -20 °C

References for anti-HTR2A antibody (ABIN966325)

Elphick, Querbes, Jordan, Gee, Eash, Manley, Dugan, Stanifer, Bhatnagar, Kroeze, Roth, Atwood: "The human polyomavirus, JCV, uses serotonin receptors to infect cells." in: Science (New York, N.Y.), Vol. 306, Issue 5700, pp. 1380-3, (2004) (PubMed).

Cook, Fletcher, Wainwright, Marks, Yan, Leventhal: "Primary structure of the human platelet serotonin 5-HT2A receptor: identify with frontal cortex serotonin 5-HT2A receptor." in: Journal of neurochemistry, Vol. 63, Issue 2, pp. 465-9, (1994) (PubMed).

Target Details for HTR2A

Target: HTR2A (5-Hydroxytryptamine (serotonin) Receptor 2A (HTR2A))

Alternative Name: HTR2A

Background: The mammalian HTR2A 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR). This is the main excitatory receptor subtype among the GPCRs for serotonin (5-HT), although 5-HT2A may also have an inhibitory effect on certain areas such as the visual cortex and the orbit frontal cortex. This receptor was given importance first as the target of psychedelic drugs like LSD. Later it came back to prominence because it was also found to be mediating, at least partly, the action of many antipsychotic drugs, especially the atypical ones.5-HT2A also happens to be a necessary receptor for the spread of the human polyoma virus called JC virus. Sparkes et al. (1991) concluded that the gene is located on 13q14-q21 in man and on chromosome 14 in the mouse.

Pathways: JAK-STAT Signaling, Inositol Metabolic Process, Regulation of Carbohydrate Metabolic Process