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IKBKB antibody (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta) (Middle Region)

Details for Product anti-IKBKB Antibody No. ABIN966380, Supplier: Log in to see
Antigen
  • ikk-beta
  • ikk2
  • ikkb
  • ikkbeta
  • IKBKB
  • IKKB
  • CG4201
  • DIK
  • DLAK
  • DmIKK
  • DmIKKBeta
  • DmIKKb
  • DmIKKbeta
  • DmIkkbeta
  • Dmel\\CG4201
  • Dmikkb
  • Dmikkbeta
  • IK
  • IKK
  • IKK-beta
  • IKKb
  • IKKbeta
  • IRD-5
  • IRD5
  • Ik
  • Ikkb
  • Ikkbeta
  • Ird-5
  • Ird5
  • LRK
  • Lak
  • anon-89Bd
  • dIKK
  • dIKK-beta
  • dIKKbeta
  • dLak
  • dmIKKbeta
  • ikk
  • ird
  • ird5/DmIkk[beta]
  • IKK2
  • NFKBIKB
  • AIM-1
  • AI132552
  • IKK-2
  • IKK[b]
Alternatives
anti-Human IKBKB antibody for Western Blotting
Epitope
Middle Region
48
29
26
22
22
21
20
20
20
20
19
19
19
19
19
19
19
14
14
14
13
9
8
7
7
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
5
5
5
5
3
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
595
150
120
14
8
2
2
1
1
Host
Rabbit
542
68
8
2
Clonality
Polyclonal
Conjugate
This IKBKB antibody is un-conjugated
36
36
36
31
31
31
9
5
5
5
5
5
5
5
5
Application
Immunohistochemistry (IHC)
294
264
227
79
62
43
42
21
12
6
5
3
3
2
1
1
Supplier
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Supplier Product No.
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to middle amino acid residues of human IKBKB (Inhibitor of nuclear factor kappa-B kinase subunit beta)
Alternative Name IKBKB (IKBKB Antibody Abstract)
Background IKBKB (Inhibitor of nuclear factor kappa-B kinase subunit beta) acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. IKBKB also phosphorylates NCOA3. Component of the I-kappa-B-kinase (IKK) core complex consists of CHUK, IKBKB and IKBKG, probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex. Part of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP. Part of a 70-90 kDa complex at least consisting of CHUK/IKKA, IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14.
Synonyms: IKKB
Pathways NF-kappaB Signaling, RTK Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway
Restrictions For Research Use only
Product cited in: Sanz, Sanchez, Lallena et al.: "The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation." in: The EMBO journal, Vol. 18, Issue 11, pp. 3044-53, 1999 (PubMed).

Nemoto, DiDonato, Lin: "Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase." in: Molecular and cellular biology, Vol. 18, Issue 12, pp. 7336-43, 1998 (PubMed).

Hu, Wang: "IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes." in: Gene, Vol. 222, Issue 1, pp. 31-40, 1999 (PubMed).

Shindo, Nakano, Sakon et al.: "Assignment of IkappaB kinase beta (IKBKB) to human chromosome band 8p12-->p11 by in situ hybridization." in: Cytogenetics and cell genetics, Vol. 82, Issue 1-2, pp. 32-3, 1998 (PubMed).

Cohen, Henzel, Baeuerle: "IKAP is a scaffold protein of the IkappaB kinase complex." in: Nature, Vol. 395, Issue 6699, pp. 292-6, 1998 (PubMed).

Background publications Bruey, Bruey-Sedano, Newman et al.: "PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages." in: The Journal of biological chemistry, Vol. 279, Issue 50, pp. 51897-907, 2004 (PubMed).

Chariot, Leonardi, Muller et al.: "Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases." in: The Journal of biological chemistry, Vol. 277, Issue 40, pp. 37029-36, 2002 (PubMed).

Wu, Qin, Hashimoto et al.: "Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase." in: Molecular and cellular biology, Vol. 22, Issue 10, pp. 3549-61, 2002 (PubMed).

Delhase, Hayakawa, Chen et al.: "Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation." in: Science (New York, N.Y.), Vol. 284, Issue 5412, pp. 309-13, 1999 (PubMed).

Woronicz, Gao, Cao et al.: "IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK." in: Science (New York, N.Y.), Vol. 278, Issue 5339, pp. 866-9, 1997 (PubMed).

Mercurio, Zhu, Murray et al.: "IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation." in: Science (New York, N.Y.), Vol. 278, Issue 5339, pp. 860-6, 1997 (PubMed).