Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) (Middle Region) antibody

Antigen: Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB)

Synonyms: IKK2, IKKB, NFKBIKB, FLJ40509, IKK-beta, MGC131801, ikk2, ikkb, ikkbeta, MGC80376, ikk-beta, IKBKB, DIK, DLAK, DmIKK, DmIKKBeta, DmIKKb, IK, IKK, IKKbeta, Ird-5, Ird5, LRK, Lak, anon-89Bd, dIKK, dIKK-beta, ird, ird5/DmIkk[beta], DmelCG4201, CG4201

Binding Site: Middle Region

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC)

Catalog no.: ABIN966380

Additional Information

Alternative name: IKBKB

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to middle amino acid residues of human IKBKB (Inhibitor of nuclear factor kappa-B kinase subunit beta)

Description: IKBKB (Inhibitor of nuclear factor kappa-B kinase subunit beta) acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. IKBKB also phosphorylates NCOA3. Component of the I-kappa-B-kinase (IKK) core complex consists of CHUK, IKBKB and IKBKG, probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex. Part of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP. Part of a 70-90 kDa complex at least consisting of CHUK/IKKA, IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14.
Synonyms: IKKB

Synonyms: IKK2, IKKB, NFKBIKB, FLJ40509, IKK-beta, MGC131801, ikk2, ikkb, ikkbeta, MGC80376, ikk-beta, IKBKB, DIK, DLAK, DmIKK, DmIKKBeta, DmIKKb, IK, IKK, IKKbeta, Ird-5, Ird5, LRK, Lak, anon-89Bd, dIKK, dIKK-beta, ird, ird5/DmIkk[beta], DmelCG4201, CG4201

Application Details

Restrictions: For Research Use only

Publications

Product: Mercurio, Zhu, Murray et al.: "IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation." in: Science (New York, N.Y.), Vol. 278, Issue 5339, pp. 860-6, 1997 (PubMed).

Woronicz, Gao, Cao et al.: "IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK." in: Science (New York, N.Y.), Vol. 278, Issue 5339, pp. 866-9, 1997 (PubMed).

Cohen, Henzel, Baeuerle: "IKAP is a scaffold protein of the IkappaB kinase complex." in: Nature, Vol. 395, Issue 6699, pp. 292-6, 1998 (PubMed).

Shindo, Nakano, Sakon et al.: "Assignment of IkappaB kinase beta (IKBKB) to human chromosome band 8p12-->p11 by in situ hybridization." in: Cytogenetics and cell genetics, Vol. 82, Issue 1-2, pp. 32-3, 1998 (PubMed).

Hu, Wang: "IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes." in: Gene, Vol. 222, Issue 1, pp. 31-40, 1999 (PubMed).

Nemoto, DiDonato, Lin: "Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase." in: Molecular and cellular biology, Vol. 18, Issue 12, pp. 7336-43, 1998 (PubMed).

Delhase, Hayakawa, Chen et al.: "Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation." in: Science (New York, N.Y.), Vol. 284, Issue 5412, pp. 309-13, 1999 (PubMed).

Sanz, Sanchez, Lallena et al.: "The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation." in: The EMBO journal, Vol. 18, Issue 11, pp. 3044-53, 1999 (PubMed).

Wu, Qin, Hashimoto et al.: "Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase." in: Molecular and cellular biology, Vol. 22, Issue 10, pp. 3549-61, 2002 (PubMed).

Chariot, Leonardi, Muller et al.: "Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases." in: The Journal of biological chemistry, Vol. 277, Issue 40, pp. 37029-36, 2002 (PubMed).

Bruey, Bruey-Sedano, Newman et al.: "PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages." in: The Journal of biological chemistry, Vol. 279, Issue 50, pp. 51897-907, 2004 (PubMed).