IKBKB antibody (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta) (Middle Region)

Details for Product anti-IKBKB Antibody No. ABIN966380, Supplier: Log in to see
Antigen
  • ikk-beta
  • ikk2
  • ikkb
  • ikkbeta
  • IKBKB
  • IKKB
  • CG4201
  • DIK
  • DLAK
  • DmIKK
  • DmIKKBeta
  • DmIKKb
  • DmIKKbeta
  • DmIkkbeta
  • Dmel\\CG4201
  • Dmikkb
  • Dmikkbeta
  • IK
  • IKK
  • IKK-beta
  • IKKb
  • IKKbeta
  • IRD-5
  • IRD5
  • Ik
  • Ikkb
  • Ikkbeta
  • Ird-5
  • Ird5
  • LRK
  • Lak
  • anon-89Bd
  • dIKK
  • dIKK-beta
  • dIKKbeta
  • dLak
  • dmIKKbeta
  • ikk
  • ird
  • ird5/DmIkk[beta]
  • IKK2
  • NFKBIKB
  • AIM-1
  • AI132552
  • IKK-2
  • IKK[b]
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
  • immune response deficient 5
  • inhibitor of kappaB kinase beta
  • ikbkb
  • IKBKB
  • ird5
  • Ikbkb
Alternatives
anti-Human IKBKB antibody for Cytometry by Time of Flight
Epitope
Middle Region
51
33
29
22
21
21
20
20
20
20
20
20
20
19
19
19
19
16
16
16
15
8
8
8
7
6
6
5
5
4
4
4
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
660
230
161
22
13
7
7
6
5
4
1
1
Host
Rabbit
556
118
9
2
Clonality
Polyclonal
Conjugate
This IKBKB antibody is un-conjugated
38
37
37
33
31
31
9
7
5
5
5
5
5
5
5
5
5
2
2
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (IHC)
311
283
264
99
75
73
68
41
37
34
6
6
6
5
3
3
2
2
1
Options
Supplier
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to middle amino acid residues of human IKBKB (Inhibitor of nuclear factor kappa-B kinase subunit beta)
Alternative Name IKBKB (IKBKB Antibody Abstract)
Background IKBKB (Inhibitor of nuclear factor kappa-B kinase subunit beta) acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. IKBKB also phosphorylates NCOA3. Component of the I-kappa-B-kinase (IKK) core complex consists of CHUK, IKBKB and IKBKG, probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex. Part of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP. Part of a 70-90 kDa complex at least consisting of CHUK/IKKA, IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14.
Synonyms: IKKB
Pathways NF-kappaB Signaling, RTK Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades
Restrictions For Research Use only
Background publications Bruey, Bruey-Sedano, Newman, Chandler, Stehlik, Reed: "PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages." in: The Journal of biological chemistry, Vol. 279, Issue 50, pp. 51897-907, 2004 (PubMed).

Chariot, Leonardi, Muller, Bonif, Brown, Siebenlist: "Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases." in: The Journal of biological chemistry, Vol. 277, Issue 40, pp. 37029-36, 2002 (PubMed).

Wu, Qin, Hashimoto, Wong, Xu, Tsai, Tsai, OMalley: "Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase." in: Molecular and cellular biology, Vol. 22, Issue 10, pp. 3549-61, 2002 (PubMed).

Delhase, Hayakawa, Chen, Karin: "Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation." in: Science (New York, N.Y.), Vol. 284, Issue 5412, pp. 309-13, 1999 (PubMed).

Mercurio, Zhu, Murray, Shevchenko, Bennett, Li, Young, Barbosa, Mann, Manning, Rao: "IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation." in: Science (New York, N.Y.), Vol. 278, Issue 5339, pp. 860-6, 1997 (PubMed).

Woronicz, Gao, Cao, Rothe, Goeddel: "IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK." in: Science (New York, N.Y.), Vol. 278, Issue 5339, pp. 866-9, 1997 (PubMed).

Product cited in: Hu, Wang: "IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes." in: Gene, Vol. 222, Issue 1, pp. 31-40, 1999 (PubMed).

Sanz, Sanchez, Lallena, Diaz-Meco, Moscat: "The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation." in: The EMBO journal, Vol. 18, Issue 11, pp. 3044-53, 1999 (PubMed).

Shindo, Nakano, Sakon, Yagita, Mihara, Okumura: "Assignment of IkappaB kinase beta (IKBKB) to human chromosome band 8p12-->p11 by in situ hybridization." in: Cytogenetics and cell genetics, Vol. 82, Issue 1-2, pp. 32-3, 1998 (PubMed).

Nemoto, DiDonato, Lin: "Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase." in: Molecular and cellular biology, Vol. 18, Issue 12, pp. 7336-43, 1998 (PubMed).

Cohen, Henzel, Baeuerle: "IKAP is a scaffold protein of the IkappaB kinase complex." in: Nature, Vol. 395, Issue 6699, pp. 292-6, 1998 (PubMed).