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MAP2K4 antibody (Mitogen-Activated Protein Kinase Kinase 4)

Details for Product anti-MAP2K4 Antibody No. ABIN966514, Supplier: Log in to see
Antigen
  • 2
  • 142758_at
  • ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
  • ATMEK4
  • ATMKK4
  • CG9738
  • CT27508
  • CT38386
  • D-MKK4
  • DmelCG12798
  • Dmel\\CG9738
  • dMkk4
  • DMKK4
  • dMKK4
  • F19C24.26
  • F19C24_26
  • hep
  • jnkk
  • JNKK
  • JNKK1
  • jnkk1
  • Jnkk2
  • JNKK2
  • map2k4
  • MAP KINASE KINASE 4
  • MAPKK4
  • mapkk4
  • Mapkk7
  • MEK4
  • mek4
  • Mek7
  • mitogen-activated protein kinase kinase 4
  • MKK4
  • mkk4
  • MKK4A-l
  • Mkk7
  • Mpk4
  • PRKMK4
  • prkmk4
  • SAPKK-1
  • SAPKK1
  • Sek1
  • sek1
  • SEK1
  • SEK1/MKK4
  • serk1
  • SERK1
  • Serk1
  • SKK1
  • xmek2
  • zgc:136500
Alternatives
anti-Human MAP2K4 antibody for Western Blotting
Reactivity
Human
292
137
107
9
8
4
4
2
Host
272
34
Clonality
Monoclonal
Conjugate
This MAP2K4 antibody is un-conjugated
12
12
11
8
8
8
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
197
139
111
58
33
17
14
13
8
6
4
3
1
Supplier
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Isotype IgM
Specificity Ni-NTA purified truncated recombinant MAP2K4 expressed in E. Coli strain BL21 (DE3)
Purification Antibodies are purified by protein A affinity chromatography
Alternative Name MAP2K4 (MAP2K4 Antibody Abstract)
Background MAP2K4(mitogen-activated protein kinase kinase 4), which is located on chromosome 17p11.2, with 399-amino acid protein (about 45 kDa), belongs to the family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. MEK-4 (also called MEK4/MKK4) activates both p38 and JNK MAP kinases. MKK4 is a central mediator in the stress activated protein kinase signaling pathway that responds to a number of cellular and environmental stressors. By phosphorylating MAP kinases such as JNK,MKK4 can ultimately transmit stress signals to nuclear transcription factors that mediate various processes including proliferation, apoptosis, and differentiation. Its distinct biological functions have been identified for MKK4 including a role in development, hepatogenesis, and metastasis suppression.
Gene ID 6416
Pathways MAPK Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway
Application Notes Western Blot: 1: 500- 1: 1,000
IHC(P): 1: 500- 1: 1,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Storage -20 °C
Product cited in: Kim, Vander Griend, Yang, Benson, Dubauskas, Yoshida, Chekmareva, Ichikawa, Sokoloff, Zhan, Karrison, Lin, Stadler, Ichikawa, Rubin, Rinker-Schaeffer: "Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers." in: Cancer research, Vol. 61, Issue 7, pp. 2833-7, 2001

Cuenda: "Mitogen-activated protein kinase kinase 4 (MKK4)." in: The international journal of biochemistry & cell biology, Vol. 32, Issue 6, pp. 581-7, 2000

Background publications Crews, Alessandrini, Erikson: "The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product." in: Science (New York, N.Y.), Vol. 258, Issue 5081, pp. 478-80, 1992