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NFKB2 antibody (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (p49/p100)) (C-Term)

Details for Product anti-NFKB2 Antibody No. ABIN966669, Supplier: Log in to see
Antigen
  • NF-kappaB2
  • lyt
  • p49
  • p49/p100
  • p50B
  • p52
Epitope
C-Term
18
15
15
13
9
6
5
5
5
4
4
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
130
57
36
2
2
2
1
1
Host
Rabbit
133
10
Clonality
Polyclonal
Conjugate
This NFKB2 antibody is un-conjugated
6
4
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC)
111
44
35
29
28
22
11
10
4
4
3
1
1
1
1
Supplier
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human NFKB2 (Nuclear factor NF-kappa-B p100 subunit)
Alternative Name NFKB2 (NFKB2 Antibody Abstract)
Background NFKB2 (Nuclear factor NF-kappa-B p100 subunit) is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappaB sites that they can bind with distinguishable affinity and specificity. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function.
Synonyms: LYT10(Lymphocyte translocation chromosome 10)
Pathways
Restrictions For Research Use only
Product cited in: Li, Nabel: "A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription." in: Molecular and cellular biology, Vol. 17, Issue 10, pp. 6184-90, 1997 (PubMed).

Bours, Franzoso, Azarenko et al.: "The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers." in: Cell, Vol. 72, Issue 5, pp. 729-39, 1993 (PubMed).

Potter, Larson, Eckes et al.: "Purification of the major histocompatibility complex class I transcription factor H2TF1. The full-length product of the nfkb2 gene." in: The Journal of biological chemistry, Vol. 268, Issue 25, pp. 18882-90, 1993 (PubMed).

Beg, Baldwin: "Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor." in: Oncogene, Vol. 9, Issue 5, pp. 1487-92, 1994 (PubMed).

Dobrzanski, Ryseck, Bravo: "Differential interactions of Rel-NF-kappa B complexes with I kappa B alpha determine pools of constitutive and inducible NF-kappa B activity." in: The EMBO journal, Vol. 13, Issue 19, pp. 4608-16, 1994 (PubMed).

Schmid, Perkins, Duckett et al.: "Cloning of an NF-kappa B subunit which stimulates HIV transcription in synergy with p65." in: Nature, Vol. 352, Issue 6337, pp. 733-6, 1991 (PubMed).

Bours, Burd, Brown et al.: "A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site." in: Molecular and cellular biology, Vol. 12, Issue 2, pp. 685-95, 1992 (PubMed).

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