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Orthodenticle Homeobox 2 (OTX2) antibody

Details for Product No. ABIN966721, Supplier: Log in to see
Antigen
  • CPHD6
  • MCOPS5
  • Xotx-2
  • Xotx2
  • otx-2
  • otx2
  • id:ibd2915
  • zOtx2
  • zgc:136535
  • zotx-2
  • E130306E05Rik
  • orthodenticle homeobox 2
  • orthodenticle homolog 2
  • orthodenticle homolog 2 (Drosophila)
  • OTX2
  • Otx2
  • otx2-a
  • otx2
Alternatives
anti-Human Orthodenticle Homeobox 2 antibody for Western Blotting
Reactivity
Human
100
37
35
10
8
7
7
7
5
4
4
4
4
3
2
2
2
2
1
1
1
Host
Mouse
71
27
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
4
4
4
2
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
73
38
32
14
13
11
10
9
4
2
1
1
Options
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Immunogen Purified recombinant fragment of human OTX2 expressed in E. Coli.
Clone 1H12G8B2
Isotype IgG1
Purification Ascitic fluid
Alternative Name OTX2 (OTX2 Antibody Abstract)
Background This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mice is required for proper forebrain development.
Tissue specificity: Expressed in brain.
Synonyms: MCOPS5, MGC45000
Molecular Weight 32kDa
Gene ID 5015
Pathways Dopaminergic Neurogenesis
Application Notes Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
Immunofluorescence: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Adamson, Shi, Wortham, Northcott, Di, Duncan, Li, McLendon, Bigner, Taylor, Yan: "OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas." in: Cancer research, Vol. 70, Issue 1, pp. 181-91, 2010 (PubMed).

Background publications Wyatt, Bakrania, Bunyan, Osborne, Crolla, Salt, Ayuso, Newbury-Ecob, Abou-Rayyah, Collin, Robinson, Ragge: "Novel heterozygous OTX2 mutations and whole gene deletions in anophthalmia, microphthalmia and coloboma." in: Human mutation, Vol. 29, Issue 11, pp. E278-83, 2008 (PubMed).