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Progesterone Receptor antibody (PGR) (AA 730-871)

Details for Product anti-PGR Antibody No. ABIN966829, Supplier: Log in to see
Antigen
  • 9930019P03Rik
  • BB114106
  • ENSMUSG00000074510
  • gb:dq017620
  • LOC443444
  • NR3C3
  • pg
  • pgr
  • PGR
  • pr
  • PR
  • PR-A
  • PR-B
  • XPR-1
  • xpr-2
Alternatives
anti-Human Progesterone Receptor antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
AA 730-871
74
53
41
37
32
27
19
18
17
17
16
15
13
11
9
8
8
7
7
7
7
6
5
5
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
569
68
66
15
6
5
4
3
2
2
1
Host
Mouse
333
247
3
Clonality (Clone)
Monoclonal ()
Conjugate
This Progesterone Receptor antibody is un-conjugated
17
15
14
9
9
9
2
2
2
2
2
2
2
2
2
Application
ELISA, Western Blotting (WB)
413
165
152
140
104
49
45
29
23
9
7
3
2
2
2
1
1
1
1
Supplier
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Immunogen Purified recombinant fragment of PGR (aa730-871) expressed in E. Coli.
Clone 8A11H1
Isotype IgG1
Purification Ascitic fluid
Alternative Name PGR (PGR Antibody Abstract)
Background PGR: progesterone receptor. This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform A only, and mediate their own response genes and physiologic effects with little overlap. The location of transcription initiation for isoform B has not been clearly determined.
Synonyms: PR, NR3C3, PGR
Gene ID 5241
Pathways Nuclear Receptor Transcription Pathway
Application Notes Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Background publications Yin, Lin, Cheng, Marsh, Utsunomiya, Ishikawa, Xue, Reierstad, Innes, Thung, Kim, Xu, Bulun: "Progesterone receptor regulates Bcl-2 gene expression through direct binding to its promoter region in uterine leiomyoma cells." in: The Journal of clinical endocrinology and metabolism, Vol. 92, Issue 11, pp. 4459-66, 2007 (PubMed).

Tung, Abdel-Hafiz, Shen, Harvell, Nitao, Richer, Sartorius, Takimoto, Horwitz: "Progesterone receptors (PR)-B and -A regulate transcription by different mechanisms: AF-3 exerts regulatory control over coactivator binding to PR-B." in: Molecular endocrinology (Baltimore, Md.), Vol. 20, Issue 11, pp. 2656-70, 2006 (PubMed).

Product cited in: Polo, José Galindo, Martínez, Alvarez, Arévalo, Asensi, Cánoves, Cáncer, Collazos, Estrada, Gómez-Candela, Johnston, Locutura, López-Aldeguer, Lozano, Miralles, Muñoz-Sanz, Ortega, Pascua, Pedrol, Pulido, San Martín, Sanz, Viciana, Chamorro,: "[Recommendations of the Study Group for Metabolic Alterations/Secretariat for the National AIDS Plan (GEAM/SPNS) on the management of metabolic and morphologic alterations in patients with HIV infection]." in: Enfermedades infecciosas y microbiología clínica, Vol. 24, Issue 2, pp. 96-117, 2006 (PubMed).

Buser, Gass-Handel, Wyszomierski, Doppler, Leonhardt, Schaack, Rosen, Watkin, Anderson, Edwards: "Progesterone receptor repression of prolactin/signal transducer and activator of transcription 5-mediated transcription of the beta-casein gene in mammary epithelial cells." in: Molecular endocrinology (Baltimore, Md.), Vol. 21, Issue 1, pp. 106-25, 2006 (PubMed).