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RAD51 Homolog Protein (LOC100368640) (Isoform 2) antibody

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Synonyms AV304093, Rad51a, Reca
Isoform 2
Human, Mouse (Murine)
Immunohistochemistry (IHC)
Pubmed 5 references available
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Quantity 0.1 mg
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human RAD51 homolog protein isoform 2
Alternative Name RAD51 homolog protein
Background RAD51 homolog protein isoform 2 is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. RAD51 homolog protein isoform 2 is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Product
Restrictions For Research Use only
Product cited in: Rebbeck, Mitra, Domchek et al.: "Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers." in: Cancer research, Vol. 69, Issue 14, pp. 5801-10, 2009 (PubMed).

Liang, Caporaso, McMaster et al.: "Common genetic variants in candidate genes and risk of familial lymphoid malignancies." in: British journal of haematology, Vol. 146, Issue 4, pp. 418-23, 2009 (PubMed).

Kovalenko, Plug, Haaf et al.: "Mammalian ubiquitin-conjugating enzyme Ubc9 interacts with Rad51 recombination protein and localizes in synaptonemal complexes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 7, pp. 2958-63, 1996 (PubMed).

Benson, Stasiak, West: "Purification and characterization of the human Rad51 protein, an analogue of E. coli RecA." in: The EMBO journal, Vol. 13, Issue 23, pp. 5764-71, 1995 (PubMed).

Background publications Shinohara, Ogawa, Matsuda et al.: "Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA." in: Nature genetics, Vol. 4, Issue 3, pp. 239-43, 1993 (PubMed).

Catalog No. ABIN966939
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