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SRY (Sex Determining Region Y)-Box 2 (SOX2) antibody

Antigen

SRY (Sex Determining Region Y)-Box 2 (SOX2)
Synonyms ANOP3, MCOPS3, MGC2413, RGD1565646, SOX2, MGC148683, lcc, ysb, Sox-2
Clonality Monoclonal (10F10)
Host
Alternatives

Mouse
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA
3 references available
Catalog no. ABIN967072
Quantity 0.1ml  (Variants)
Price 426.25 $   Plus shipping costs $45.00
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Additional Information
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Alternative name SOX2
Gene ID 20674
Immunogen Purified recombinant fragment of human SOX2 expressed in E. Coli.
Isotype IgG1
Clone 10F10
Description Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.
Synonyms: lcc, ysb, Sox-2, Sox2
Molecular Weight 34kDa

Application Details
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Application Notes Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
Immunofluorescence: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Purification Ascitic fluid
Preservative 0.03% sodium azide.
Storage Store at 4°C, for long term storage, store at -20°C.
Research Area Embryogenesis, Embryonic stem cells, Reproduction, Transcription Factors, Neural Stem Cell marker
Restrictions For Research Use only

Publications
Application Details Alternatives Variants back to top

Product Tay, Zhang, Thomson et al.: "MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation." in: Nature, Vol. 455, Issue 7216, pp. 1124-8, 2008 (PubMed).

Qin, Gan, Shao et al.: "Mouse meningiocytes express Sox2 and yield high efficiency of chimeras after nuclear reprogramming with exogenous factors." in: The Journal of biological chemistry, Vol. 283, Issue 48, pp. 33730-5, 2008 (PubMed).

Dabdoub, Puligilla, Jones et al.: "Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 47, pp. 18396-401, 2008 (PubMed).

Alternatives
Application Details Publications Variants back to top

Alternatives for antigen "SRY (Sex Determining Region Y)-Box 2 (SOX2)", type "Antibodies"
Hosts Rabbit (90), Mouse (18), Goat (4)
Reactivities Human (107), Mouse (Murine) (41), Rat (Rattus) (32), Dog (Canine) (23), Pig (Porcine) (23), Chicken (22), Cow (Bovine) (22), Sheep (Ovine) (20), Guinea Pig (18), Xenopus laevis (2), Zebrafish (2), Zebrafish (Danio rerio) (2), Cat (Feline) (1), Chimpanzee (1), Monkey (1), Opossum (Didelphimorphia) (1), Rhesus Monkey (1), Salmon (Salmonidae) (1)
Applications Western Blotting (WB) (77), ELISA (56), Immunofluorescence (IF) (32), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (21), Immunohistochemistry (IHC) (13), Immunocytochemistry (ICC) (10), Dot Blot (Dot) (6), Flow Cytometry (FACS) (6), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoprecipitation (IP) (3), Immunoelectron Microscopy (IEM) (1)
Conjugates Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)
Epitopes N-Term (9), C-Term (3), AA 1-170 (2), Ala30 (2), Cys265 (2), Internal Region (2), AA 50-100 (1), C-Term, AA 240-260 (1), Center (1), pSer246 (1), pSer249 (1), pSer250 (1), pSer251 (1), pSer83 (1), pTyr108 (1)