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Toll-Like Receptor 9 (TLR9) (C-Term) antibody

Details for Product No. ABIN967189, Supplier: Login to see
Antigen
  • CD289
Alternatives
anti-Mouse (Murine) Toll-Like Receptor 9 antibody for Immunohistochemistry (Frozen Sections)
Epitope
C-Term
48
35
19
16
15
9
8
7
6
5
5
5
4
4
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Mouse (Murine)
211
92
27
4
3
2
2
1
1
1
1
1
Host
Rabbit
128
84
23
16
4
2
Clonality
Polyclonal
Conjugate
Un-conjugated
25
23
14
7
6
4
1
Application
Immunohistochemistry (IHC)
196
105
83
75
55
37
16
16
7
7
6
4
3
3
3
3
2
2
1
Supplier
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of mouse Tlr9 (Toll-like receptor 9)
Alternative Name Tlr9 (TLR9 Antibody Abstract)
Background Tlr9 (Toll-like receptor 9) participates in the innate immune response to microbial agents. Tlr9 (Toll-like receptor 9) detects the unmethylated cytidine-phosphate-guanosine (CpG) motifs present in bacterial DNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Tlr9 (Toll-like receptor 9) plays a role in defense against sytemic mouse cytomegalovirus infection. Tlr9 (Toll-like receptor 9) binds MYD88 via their respective TIR domains and interacts with CNPY3. Tlr9 (Toll-like receptor 9) belongs to the Toll-like receptor family and contains 26 LRR (leucine-rich) repeats and 1 TIR domain.
Pathways TLR Signaling
Restrictions For Research Use only
Product cited in: Kiyokawa, Akashi-Takamura, Shibata et al.: "A single base mutation in the PRAT4A gene reveals differential interaction of PRAT4A with Toll-like receptors." in: International immunology, Vol. 20, Issue 11, pp. 1407-15, 2008 (PubMed).

Tabeta, Georgel, Janssen et al.: "Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 10, pp. 3516-21, 2004 (PubMed).

Chuang, Lee, Kline et al.: "Toll-like receptor 9 mediates CpG-DNA signaling." in: Journal of leukocyte biology, Vol. 71, Issue 3, pp. 538-44, 2002 (PubMed).

Bauer, Kirschning, Häcker et al.: "Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 16, pp. 9237-42, 2001 (PubMed).

Background publications Hemmi, Takeuchi, Kawai et al.: "A Toll-like receptor recognizes bacterial DNA." in: Nature, Vol. 408, Issue 6813, pp. 740-5, 2000 (PubMed).