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Toll-Like Receptor 9 (TLR9) (N-Term) antibody

Antigen

Toll-Like Receptor 9 (TLR9)
Synonyms CD289
Binding Site
Alternatives

N-Term
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Mouse (Murine)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunohistochemistry (IHC)
5 references available
Catalog no. ABIN967190
Quantity 0.1mg
Price 452.38 $   Plus shipping costs $45.00
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Alternative name Tlr9
Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of mouse Tlr9 (Toll-like receptor 9)
Description Tlr9 (Toll-like receptor 9) participates in the innate immune response to microbial agents. Tlr9 (Toll-like receptor 9) detects the unmethylated cytidine-phosphate-guanosine (CpG) motifs present in bacterial DNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Tlr9 (Toll-like receptor 9) plays a role in defense against sytemic mouse cytomegalovirus infection. Tlr9 (Toll-like receptor 9) binds MYD88 via their respective TIR domains and interacts with CNPY3. Tlr9 (Toll-like receptor 9) belongs to the Toll-like receptor family and contains 26 LRR (leucine-rich) repeats and 1 TIR domain.

Application Details
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Restrictions For Research Use only

Publications
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Product Hemmi, Takeuchi, Kawai et al.: "A Toll-like receptor recognizes bacterial DNA." in: Nature, Vol. 408, Issue 6813, pp. 740-5, 2000 (PubMed).

Bauer, Kirschning, Häcker et al.: "Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 16, pp. 9237-42, 2001 (PubMed).

Chuang, Lee, Kline et al.: "Toll-like receptor 9 mediates CpG-DNA signaling." in: Journal of leukocyte biology, Vol. 71, Issue 3, pp. 538-44, 2002 (PubMed).

Tabeta, Georgel, Janssen et al.: "Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 10, pp. 3516-21, 2004 (PubMed).

Kiyokawa, Akashi-Takamura, Shibata et al.: "A single base mutation in the PRAT4A gene reveals differential interaction of PRAT4A with Toll-like receptors." in: International immunology, Vol. 20, Issue 11, pp. 1407-15, 2008 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "Toll-Like Receptor 9 (TLR9)", type "Antibodies"
Hosts Rabbit (67), Mouse (46), Rat (8), Goat (5), Chicken (3)
Reactivities Human (104), Mouse (Murine) (72), Rat (Rattus) (38), Dog (Canine) (28), Horse (Equine) (24), Pig (Porcine) (21), Cow (Bovine) (19), Sheep (Ovine) (18), Monkey (9), Chimpanzee (1)
Applications Western Blotting (WB) (97), Flow Cytometry (FACS) (49), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (46), Immunofluorescence (IF) (30), ELISA (28), Immunohistochemistry (Fixed) (IHC (fx)) (25), Immunocytochemistry (ICC) (18), Immunohistochemistry (IHC) (15), Immunohistochemistry (Frozen Sections) (IHC (fro)) (12), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Dot Blot (DB) (1), Dot Blot (Dot) (1), Electrophoretic Mobility-Shift Assay (EMSA) (1), Enzyme Immunoassay (EIA) (1), Immunoassay (IA) (1), Immunoelectron Microscopy (IEM) (1), Immunoprecipitation (IP) (1)
Conjugates Biotin (14), FITC (11), PE (5), Alexa Fluor (2), Alexa Fluor 488 (2), Alexa Fluor 647 (2), Alexa Fluor 350 (1), Alexa Fluor 555 (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), Gold (1), HRP (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), Pacific Blue (1)
Epitopes C-Term (14), AA 268-284 (13), AA 1-815 (11), AA 268-284,Isoform A (5), N-Term (5), Cytoplasmic Domain (4), Internal Region (3), AA 1050-1100 (1), AA 200-300 (1), AA 205-235 (1), AA 311-465,Isoform A (1), AA 437-455 (1), C-Term,AA 841-870 (1), Center (1), Middle Region (1), internal (1)