FIGF antibody (C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D)) (Middle Region)

Details for Product anti-Figf Antibody No. ABIN967243, Supplier: Log in to see
Antigen
  • FIGF
  • vegfd
  • vegf-d
  • VEGFD
  • AI325264
  • VEGF-D
  • Vegfd
  • Vegf-d
  • c-fos induced growth factor (vascular endothelial growth factor D)
  • c-fos induced growth factor
  • Vascular endothelial growth factor D
  • FIGF
  • figf
  • vegfd
  • Figf
Alternatives
anti-Human FIGF antibody for ELISA
Epitope
Middle Region
17
14
13
10
10
9
8
8
7
5
5
4
1
1
1
Reactivity
Human
130
29
24
3
1
1
Host
Rabbit
103
31
3
Clonality
Polyclonal
Conjugate
This FIGF antibody is un-conjugated
9
8
7
4
4
4
2
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
116
56
56
21
7
4
3
2
1
Options
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Immunogen A synthetic peptide corresponding to a sequence in the middle region of human VEGFD , identical to the related rat and mouse sequences.< br/>Immunogen was affinity purified.
Isotype IgG
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Cross-Reactivity (Details) No cross reactivity with other proteins.
Characteristics Rabbit IgG polyclonal antibody for Vascular endothelial growth factor D (FIGF) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
Alternative Name Vascular endothelial growth factor D (Figf Antibody Abstract)
Background C-fos induced growth factor (FIGF) (or vascular endothelial growth factor D, VEGF-D) is a vascular endothelial growth factor that in humans is encoded by the FIGF gene. The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. Analyzing by Northern blotting, Yamada et al. (1997) symbolized VEGFD, was expressed as a 2. 2-kb transcript with highest expression in lung, heart, small intestine, and fetal lung, and lower levels in skeletal muscle, colon, and pancreas. And Achen et al. (1998) concluded that VEGFD was most closely related to VEGFC by virtue of the presence of N- and C-terminal extensions that were not found in other VEGF family members. Stacker et al. (2001) showed that VEGFD can induce tumor angiogenesis through VEGFR2 and tumor lymphangiogenesis through VEGFR3, whereas VEGF, which does not activate VEGFR3, induces only tumor angiogenesis.
Pathways RTK Signaling
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
Preservative Sodium azide, Thimerosal (Merthiolate)
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
Product cited in: Stacker, Caesar, Baldwin, Thornton, Williams, Prevo, Jackson, Nishikawa, Kubo, Achen: "VEGF-D promotes the metastatic spread of tumor cells via the lymphatics." in: Nature medicine, Vol. 7, Issue 2, pp. 186-91, 2001 (PubMed).

Yamada, Nezu, Shimane, Hirata: "Molecular cloning of a novel vascular endothelial growth factor, VEGF-D." in: Genomics, Vol. 42, Issue 3, pp. 483-8, 1997 (PubMed).

Background publications Achen, Jeltsch, Kukk, Mäkinen, Vitali, Wilks, Alitalo, Stacker: "Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 2, pp. 548-53, 1998 (PubMed).