Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Cross-Reactivity
Mouse (Murine), Rat (Rattus)
Cross-Reactivity (Details)
No cross reactivity with other proteins.
Characteristics
Rabbit IgG polyclonal antibody for Vascular endothelial growth factor D (FIGF) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human VEGFD , identical to the related rat and mouse sequences.< br/>Immunogen was affinity purified.
C-fos induced growth factor (FIGF) (or vascular endothelial growth factor D, VEGF-D) is a vascular endothelial growth factor that in humans is encoded by the FIGF gene. The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. Analyzing by Northern blotting, Yamada et al. (1997) symbolized VEGFD, was expressed as a 2. 2-kb transcript with highest expression in lung, heart, small intestine, and fetal lung, and lower levels in skeletal muscle, colon, and pancreas. And Achen et al. (1998) concluded that VEGFD was most closely related to VEGFC by virtue of the presence of N- and C-terminal extensions that were not found in other VEGF family members. Stacker et al. (2001) showed that VEGFD can induce tumor angiogenesis through VEGFR2 and tumor lymphangiogenesis through VEGFR3, whereas VEGF, which does not activate VEGFR3, induces only tumor angiogenesis.