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Solute Carrier Family 39 (Zinc Transporter), Member 4 (SLC39A4) (N-Term) antibody

Details for Product No. ABIN967275, Supplier: Log in to see
Antigen
  • AEZ
  • AWMS2
  • ZIP4
  • 1600025H15Rik
  • AU041686
Epitope
N-Term
15
5
2
2
1
1
1
Reactivity
Human
42
3
3
1
1
1
Host
Rabbit
30
13
1
Clonality
Polyclonal
Conjugate
Un-conjugated
1
1
1
1
1
1
Application
Immunohistochemistry (IHC)
30
26
4
1
1
Supplier
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human ZIP4 (Zinc transporter ZIP4)
Alternative Name ZIP4 (SLC39A4 Antibody Abstract)
Background ZIP4 (Zinc transporter ZIP4) plays an important role in cellular zinc homeostasis as a zinc transporter. ZIP4 is regulated in response to zinc availability. ZIP4 is a multi-pass membrane protein and is colocalized with TFRC in the recycling endosomes. ZIP4 cycles between endosomal compartments and the plasma membrane in response to zinc availability. ZIP4 is highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum. Defects in SLC39A4 are the cause of acrodermatitis enteropathica zinc-deficiency type (AEZ). AEZ is a rare autosomal recessive disease caused by the inability to absorb sufficient zinc. The clinicals features are growth retardation, immune system dysfunction, alopecia, severe dermatitis, diarrhea and occasionally mental disorders. All these manifestations are reversible with zinc supplementation. Without zinc therapy this disease is fatal. ZIP4 belongs to the ZIP transporter (TC 2.A.5) family.
Synonyms: SLC39A4 (Solute carrier family 39 member 4), ZIP-4 (Zrt- and Irt-like protein 4)
Pathways
Restrictions For Research Use only
Product cited in: Kim, Wang, Dufner-Beattie et al.: "Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane." in: The Journal of biological chemistry, Vol. 279, Issue 6, pp. 4523-30, 2004 (PubMed).

Küry, Dréno, Bézieau et al.: "Identification of SLC39A4, a gene involved in acrodermatitis enteropathica." in: Nature genetics, Vol. 31, Issue 3, pp. 239-40, 2002 (PubMed).

Wang, Zhou, Kuo et al.: "A novel member of a zinc transporter family is defective in acrodermatitis enteropathica." in: American journal of human genetics, Vol. 71, Issue 1, pp. 66-73, 2002 (PubMed).

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