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Details for Product No. ABIN967289

Keratin 7 (KRT7) antibody

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Antigen
Synonyms CK7, K2C7, K7, SCL, D15Wsu77e, Krt2-7, KRT7
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 3 references available
Catalog no. ABIN967289
Quantity 50 µg
Price
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Immunogen Cytokeratins from the human bladder carcinoma cell line T24
Clone RCK105
Isotype IgG1
Cross-Reactivity Mouse (Murine), Rat (Rattus), Hamster, Dog (Canine), Pig (Porcine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name Cytokeratin 7
Background Intermediate filaments (IF) are a subset of cytoskeletal proteins which function to give overall structural integrity to the plasma membrane as well as organize cells into specific tissues. IF proteins can be divided into six major types based upon similarity in sequence. Type I and II IF proteins are designated keratins based upon whether they are acidic (I) or basic (II) and are characterized by their remarkable biochemical diversity. A subgroup of keratins, designated cytokeratins, are represented in epithelial tissues by at least 20 different polypeptides, designated 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin 7 is found in both columnar and glandular epithelium of the lung, cervix, breast, bile ducts, and in the collecting ducts in the kidney as well as mesothelium. The molecular weight of cytokeratin 7 is approximately 54 kDa in SDS/PAGE.
Molecular Weight 55 kDa
Research Area Signaling, Cytoskeleton, Cytokeratins, Extracellular Matrix
Application Notes Applications include western blot analysis. Additional applications include immunohistochemistry on methanol fixed tissue, but this application is not tested.
Comment

Related Products: ABIN968535, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/ml
Buffer Aqueous buffered solution.
Preservative Sodium azide
Storage 4 °C
Product cited in: Smedts, Ramaekers, Robben et al.: "Changing patterns of keratin expression during progression of cervical intraepithelial neoplasia." in: The American journal of pathology, Vol. 136, Issue 3, pp. 657-68, 1990 (PubMed).

Ramaekers, Huysmans, Schaart et al.: "Tissue distribution of keratin 7 as monitored by a monoclonal antibody." in: Experimental cell research, Vol. 170, Issue 1, pp. 235-49, 1987 (PubMed).

Broers, Ramaekers, Rot et al.: "Cytokeratins in different types of human lung cancer as monitored by chain-specific monoclonal antibodies." in: Cancer research, Vol. 48, Issue 11, pp. 3221-9, 1988 (PubMed).

Alternatives for antigen "Keratin 7 (KRT7)", type "Antibodies"
Hosts (116), (94), (3)
Reactivities (180), (47), (40), (10), (10), (10), (5), (5), (5), (3), (1), (1), (1)
Applications (136), (94), (48), (44), (44), (37), (32), (30), (20), (15), (11), (7), (5), (2), (1), (1)
Conjugates (11), (7), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Epitopes (13), (9), (2), (2), (2), (2), (2), (1), (1)
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