Integrin beta 3 antibody (ITGB3)

Details for Product anti-ITGB3 Antibody No. ABIN967485, Supplier: Log in to see
Antigen
  • CD61
  • GP3A
  • INGRB3
  • BDPLT16
  • BDPLT2
  • GPIIIa
  • GT
  • INTB3
  • integrin
  • GPIIIA
  • integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
  • integrin beta 3
  • integrin, beta 3
  • ITGB3
  • Itgb3
Alternatives
anti-Human Integrin beta 3 antibody for Flow Cytometry
Reactivity
Baboon, Cow (Bovine), Cynomolgus, Human, Rhesus Monkey
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Host
Mouse
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Clonality (Clone)
Monoclonal ()
Conjugate
This Integrin beta 3 antibody is un-conjugated
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Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Western Blotting (WB)
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Options
Supplier
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Supplier Product No.
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Brand BD Pharmingen™
Clone VI-PL2
Isotype IgG1, kappa
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name CD61 (ITGB3 Antibody Abstract)
Background Reacts with integrin beta3, a 105 kDa transmembrane glycoprotein, expressed on platelets, megakaryocytes, osteoclasts and endothelia. Integrin beta3 associates with gpIIa (CD41) to form the CD41/CD61 complex which mediates platelet adhesion and aggregation. CD61 also associates with CD51 to form the CD51/CD61 complex (vitronectin receptor). CD61 appears to bind to fibrinogen, fibronectin, vWF, vitronectin, and thrombospondin to mediate cell adhesion. This antibody is routinely tested by flow cytometric analysis.
Synonyms: Integrin beta3 Chain
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store undiluted at 4° C.
Supplier Images
 image for anti-Integrin beta 3 (ITGB3) antibody (ABIN967485) Profile of peripheral blood platelets analyzed by flow cytometry
Product cited in: Mason, André, Bensussan, Buckley, Civin, Clark, de Haas, Goyert, Hadam, Hart, Horejsí, Meuer, Morissey, Schwartz-Albiez, Shaw, Simmons, Uguccioni, van der Schoot, Viver, Zola: "CD antigens 2001." in: Tissue antigens, Vol. 58, Issue 6, pp. 425-30, 2002 (PubMed).

Background publications Komori, Yagi, Nomura, Yamaguchi, Sasaki, Deguchi, Shimizu, Bronson, Gao, Inada, Sato, Okamoto, Kitamura, Yoshiki, Kishimoto: "Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts." in: Cell, Vol. 89, Issue 5, pp. 755-64, 1997 (PubMed).

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