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SNCA antibody (Synuclein, alpha) (Tyr125)

Details for Product anti-SNCA Antibody No. ABIN967584, Supplier: Log in to see
Antigen
  • snca
  • MGC64356
  • LOC619283
  • NACP
  • alphaSYN
  • PARK1
  • PARK4
  • PD1
  • synuclein, alpha
  • alpha-synuclein
  • synuclein, alpha (non A4 component of amyloid precursor)
  • snca
  • LOC619283
  • LOC100359228
  • Snca
  • SNCA
Epitope
Tyr125, pTyr125
67
48
42
39
36
34
31
20
13
12
12
10
7
6
6
6
5
5
5
4
4
4
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
619
266
261
16
14
11
11
8
4
2
2
2
1
1
1
Host
Mouse
405
197
35
10
4
2
Clonality (Clone)
Monoclonal ()
Conjugate
This SNCA antibody is un-conjugated
27
26
21
11
11
6
6
6
6
6
6
6
5
5
5
5
5
5
4
4
4
4
4
4
4
1
1
Application
Western Blotting (WB)
469
254
150
124
100
67
52
23
22
21
17
10
8
7
3
2
2
1
1
1
1
Options
Supplier
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Brand BD Pharmingen™
Immunogen Phosphorylated peptide corresponding to the region including the Tyrosine 125 residue of alpha-Synuclein
Clone I57-628
Isotype IgG2b, kappa
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3. Please refer to us for technical protocols.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name alpha Synuclein (SNCA Antibody Abstract)
Background The 140-amino-acid alpha-Synuclein protein is identical to the non-amyloid-beta component precursor (NACP), a presynaptic protein involved in amyloidogenesis in Alzheimer's disease (AD). This protein is expressed in brain, primarily in presynaptic nerve terminals. Although the exact function of the Synucleins has not been determined, they have been linked to the prominent neurodegenerative disorders AD and Parkinson's disease. The Tyrosine 125 (Y125) residue of alpha-Synuclein plays an important role in stress-induced dimerization of the protein and is phosphorylated by Pyk/RAFTK via the Src-family kinases Fyn and c-Src.
The I57-628 antibody recognizes alpha-Synuclein phosphorylated at Y125.
Molecular Weight 19 kDa
Research Area Neurology, Alzheimer's Disease
Comment

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store undiluted at 4°C.
Supplier Images
Western Blotting (WB) image for anti-SNCA antibody (Synuclein, alpha) (Tyr125) (ABIN967584) Western blot analysis of alpha-Synuclein (pY125). Lysates from control (first panel) ...
Product cited in: Forman, Trojanowski, Lee: "Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs." in: Nature medicine, Vol. 10, Issue 10, pp. 1055-63, 2004 (PubMed).

Nakamura, Yamashita, Nagano, Takahashi, Avraham, Avraham, Matsumoto, Nakamura: "Activation of Pyk2/RAFTK induces tyrosine phosphorylation of alpha-synuclein via Src-family kinases." in: FEBS letters, Vol. 521, Issue 1-3, pp. 190-4, 2002 (PubMed).

Takahashi, Yamashita, Nakamura, Nagano, Nakamura: "Tyrosine 125 of alpha-synuclein plays a critical role for dimerization following nitrative stress." in: Brain research, Vol. 938, Issue 1-2, pp. 73-80, 2002 (PubMed).

Ellis, Schwartzberg, Grider, Fink, Nussbaum: "alpha-synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases." in: The Journal of biological chemistry, Vol. 276, Issue 6, pp. 3879-84, 2001 (PubMed).

Nakamura, Yamashita, Takahashi, Nakamura: "Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125." in: Biochemical and biophysical research communications, Vol. 280, Issue 4, pp. 1085-92, 2001 (PubMed).