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JNK antibody (Mitogen-Activated Protein Kinase 8) (pThr183)

Details for Product anti-MAPK8 Antibody No. ABIN968867, Supplier: Login to see New
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BSK, BSK/DJNK, Bsk, CG5680, D-JNK, D-junk, DBSK/JNK, DJNK, DJNK/bsk, Dmel\\CG5680, JNK, JNK/SAPK, Jnk, Junk, SAPKa, c-Jun, dJNK, jnk, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c, AI849689, P ... show more
BSK, BSK/DJNK, Bsk, CG5680, D-JNK, D-junk, DBSK/JNK, DJNK, DJNK/bsk, Dmel\\CG5680, JNK, JNK/SAPK, Jnk, Junk, SAPKa, c-Jun, dJNK, jnk, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c, AI849689, Prkm8, jnk1, sapk1, T10F20.15, mapk8, zgc:112379 show less
(96), (60), (33), (22), (18), (15), (15), (15), (13), (13), (13), (10), (10), (10), (10), (6), (6), (6), (5), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(374), (130), (109), (17), (15), (7), (6), (4), (2), (2), (2), (1), (1), (1)
(311), (91), (2)
Clonality (Clone)
Monoclonal ()
This JNK antibody is un-conjugated
(18), (16), (14), (11), (11), (10), (4), (3), (3), (3), (3), (3), (3), (3), (3)
Flow Cytometry (FACS), Western Blotting (WB)
(301), (197), (86), (67), (52), (51), (39), (33), (18), (17), (9), (8), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Pubmed 5 references available
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Quantity 150 μg
Shipping to United States ( )
Immunogen Phosphorylated Human JNK/SAPK (pT183/pY185) Peptide
Clone 41-JNK-SAPK
Isotype IgG1
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name JNK (MAPK8 Antibody Abstract)
Background The Ras signaling pathway links the signals from growth factor receptors with the activation of the MAPK kinase cascade of phosphorylation leading to cell growth and differentiation. External stimuli, like endotoxins, UV irradiation, heat, and hyperosmolarity, induce an array of cellular responses that culminate with gene expression, ultimately dictating an adaptation to the new environment. Small GTPases of the Rho family, including cdc42, Rac1, and Rho, transmit the stress signals that initiate the signal cascade. JNK is a c-Jun kinase that was also identified as SAPK1 and MAPKp49. JNK/SAPK, along with p38 and RK5/BMK1, comprise three classes of stress-activated MAPK groups. Complete activation of JNK/SAPK requires the phosphorylation of both Thr183 and Tyr185, which are located in a Thr-X-Tyr motif. The activation of these residues is believed to be carried out by MKK4 and MKK7. Active JNK/SAPK phosphorylates other kinases and multiple transcription factors that induce expression of genes, such as proinflammatory cytokines.
Molecular Weight 43 & 56 kDa
Pathways MAPK Signaling, WNT Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway

Related Products: ABIN968535, ABIN968632, ABIN967389, ABIN968074

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-JNK antibody (Mitogen-Activated Protein Kinase 8) (pThr183) (ABIN968867) Western blot analysis for JNK/SAPK (pT183/pY185). HeLa cells (Human cervical epithelo...
Product cited in: Kyriakis, Avruch: "Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation." in: Physiological reviews, Vol. 81, Issue 2, pp. 807-69, 2001 (PubMed).

Muyembe, Maes, Makulu et al.: "The hem of the garment." in: Seminars in dialysis, Vol. 14, Issue 1, pp. 76, 2001 (PubMed).

Fleming, Armstrong, Morrice et al.: "Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7." in: The Biochemical journal, Vol. 352 Pt 1, Issue 3, pp. 145-54, 2001 (PubMed).

Mohit, Martin, Miller: "p493F12 kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous system." in: Neuron, Vol. 14, Issue 1, pp. 67-78, 1995 (PubMed).

Hinton, Henderson, Blanks et al.: "Monoclonal antibodies react with neuronal subpopulations in the human nervous system." in: The Journal of comparative neurology, Vol. 267, Issue 3, pp. 398-408, 1988 (PubMed).

Catalog No. ABIN968867
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