Cyclin-Dependent Kinase 1 (CDK1) antibody

Details for Product No. ABIN969034
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms
5363, CDC2, CDCDm, CDK1, CDK1/CDC2, CG5363, Cdc2, Cdk-1, Cdk1, Dcdc2, Dm cdc2, DmCdc2, DmCdk1, Dmcdc2, Dmel\\CG5363, cdc, cdc2Dm, cdk1, dCdk1, group 4, l(2)31Eh, CDC28A, P34CDC2, Cdc2a, p34, cdc ... show more
5363, CDC2, CDCDm, CDK1, CDK1/CDC2, CG5363, Cdc2, Cdk-1, Cdk1, Dcdc2, Dm cdc2, DmCdc2, DmCdk1, Dmcdc2, Dmel\\CG5363, cdc, cdc2Dm, cdk1, dCdk1, group 4, l(2)31Eh, CDC28A, P34CDC2, Cdc2a, p34, cdc2, wu:fc30e01, zgc:92032, PSTAIR, cdc-2, cdc2-a, cdc28a, cdc2x1.1, p34cdc2, xcdc2, CDC2A, CDC2AAT, CDK2, CDKA1, CDKA;1, CYCLIN-DEPENDENT KINASE A;1, cell division control 2, POL3, pold show less
Reactivity
Human
(529), (265), (254), (45), (37), (30), (27), (26), (16), (7), (6), (4), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Host
Mouse
(438), (131)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(22), (16), (15), (9), (9), (9), (6), (6), (6), (6), (6), (6), (6), (6), (1), (1)
Application
ELISA, Western Blotting (WB), Immunocytochemistry (ICC), Fluorescence Microscopy (FM)
(479), (204), (127), (119), (77), (71), (60), (41), (28), (24), (21), (12), (10), (10), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Pubmed 2 references available
Quantity 100 μL
Options
Shipping to United States (Change)
Availability Will be delivered in 3 to 4 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN969034
363.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Purified recombinant fragment of CDC2 expressed in E. coli.
Clone 8C5A7F10
Isotype IgG1
Purification Ascites
Alternative Name CDC2
Background Synonyms:
CDC2, CDC28A, P34CDC2, MGC111195, DKFZp686L20222, CDK1
The cell division control protein cdc2, also known as cyclin-dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S-phase and mitosis. Cdc2 exists as a complex with both cyclin A and cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2δT is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration.
Molecular Weight 34 kDa
Gene ID 983
Research Area Cell Cycle
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-Cyclin-Dependent Kinase 1 (CDK1) antibody Figure 3: Flow cytometric analysis of PC-2 cells using CDC2 mouse mAb (green) and negative control (purple) .
anti-Cyclin-Dependent Kinase 1 (CDK1) antibody (2) Figure 2: Immunofluorescence analysis of Hela cells using CDC2 mouse mAb (green) . Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
anti-Cyclin-Dependent Kinase 1 (CDK1) antibody (3) Figure 1: Western blot analysis using CDC2 mouse mAb against Jurkat (1) cell lysate.
Product cited in: Tang, Wu, Guo et al.: "Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition." in: Molecular biology of the cell, Vol. 19, Issue 8, pp. 3536-43, 2008 (PubMed).

Meyer, Merkel, Brückl et al.: "Cdc2 as prognostic marker in stage UICC II colon carcinomas." in: European journal of cancer (Oxford, England : 1990), Vol. 45, Issue 8, pp. 1466-73, 2009 (PubMed).

Validation Images
Did you look for something else?
back to top