CTNNB1 antibody (Catenin (Cadherin-Associated Protein), beta 1, 88kDa)

Details for Product anti-CTNNB1 Antibody No. ABIN969072, Supplier: Log in to see
Antigen
  • Jup
  • LOC100217813
  • CTNNB1
  • CTNNB
  • Bfc
  • Catnb
  • Mesc
  • ctnnb
  • id:ibd2058
  • wu:fb73e10
  • wu:fi81c06
  • wu:fk25h01
  • ctnnb1
  • CHBCAT
  • MRD19
  • armadillo
  • beta-catenin
  • catenin (cadherin-associated protein), beta 1, 88kDa
  • catenin (cadherin associated protein), beta 1
  • catenin (cadherin-associated protein), beta 1
  • CTNNB1
  • LOC100217813
  • Ctnnb1
  • ctnnb1
  • ctnnb1-a
  • ctnnb1-b
Alternatives
anti-Human CTNNB1 antibody for Chromatin Immunoprecipitation
Reactivity
Human
449
213
189
62
53
36
26
24
22
20
15
15
15
10
9
9
3
1
1
1
1
1
1
Host
Mouse
296
161
5
2
Clonality (Clone)
Monoclonal ()
Conjugate
This CTNNB1 antibody is un-conjugated
14
11
8
7
6
6
4
4
2
2
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
407
143
107
107
104
79
70
30
16
13
8
8
4
3
3
2
1
1
Options
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Immunogen Purified recombinant fragment of human CTNNB1 expressed in E. Coli.
Clone 4D5
Isotype IgG1
Purification Ascites
Alternative Name CTNNB1 (CTNNB1 Antibody Abstract)
Background The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. The distinct peripheral cytosolic proteins, alpha, beta and gamma catenin (102, 94 and 86 kDa) are found in many tissues and bind to the conserved cytoplasmic tail domain of the cell adhesion cadherins. Catenins link E cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt1 proto oncogene. The central core region of beta catenin is involved in mediation of cadherin catenin complex interaction with EGFR. Beta-Catenin-mediated signalling is involved at several stages of vertebrate neural development.
Molecular Weight 85 kDa
Gene ID 1499
HGNC 1499
Pathways WNT Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Tube Formation, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
Flow Cytometry (FACS) image for anti-CTNNB1 antibody (Catenin (Cadherin-Associated Protein), beta 1, 88kDa) (ABIN969072) Figure 1: Flow cytometric analysis of A549 cells using CTNNB1 mouse mAb (green) and n...
Immunocytochemistry (ICC) image for anti-CTNNB1 antibody (Catenin (Cadherin-Associated Protein), beta 1, 88kDa) (ABIN969072) Figure 2: Immunofluorescence analysis of A549 (left) and SK-BR-3 (right) cells using ...
Immunohistochemistry (IHC) image for anti-CTNNB1 antibody (Catenin (Cadherin-Associated Protein), beta 1, 88kDa) (ABIN969072) Figure 3: Immunohistochemical analysis of paraffin-embedded human Placenta tissues us...
Western Blotting (WB) image for anti-CTNNB1 antibody (Catenin (Cadherin-Associated Protein), beta 1, 88kDa) (ABIN969072) Figure 4: Western blot analysis using CTNNB1 mouse mAb against CTNNB1-hIgGFc transfec...
Product cited in: Bougatef, Ouerhani, Moussa, Kourda, Coulet, Colas, Lahely, Najjar, Ben Jilani, Benammar-Elgaaied, Soubrier, Marrakchi: "Prevalence of mutations in APC, CTNNB1, and BRAF in Tunisian patients with sporadic colorectal cancer." in: Cancer genetics and cytogenetics, Vol. 187, Issue 1, pp. 12-8, 2008 (PubMed).

Guo, Liu, Yang, Zhang, Yao: "Relation among p130Cas, E-cadherin and beta-catenin expression, clinicopathologic significance and prognosis in human hepatocellular carcinoma." in: Hepatobiliary & pancreatic diseases international : HBPD INT, Vol. 7, Issue 5, pp. 490-6, 2008 (PubMed).

Background publications Rubinfeld, Souza, Albert, Munemitsu, Polakis: "The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin." in: The Journal of biological chemistry, Vol. 270, Issue 10, pp. 5549-55, 1995 (PubMed).