Fibulin 5 (FBLN5) antibody

Details for Product No. ABIN969145
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Antigen
Synonyms zgc:103575, FBLN5, MGC108414, Fibulin-5, DKFZp469K0327, ADCL2, ARCL1A, ARMD3, DANCE, EVEC, FIBL-5, UP50, A55
Reactivity
Human
(82), (28), (25), (13), (4), (1), (1), (1)
Host
Mouse
(48), (32), (6)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(5), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(78), (59), (24), (16), (10), (9), (7), (1), (1)
Pubmed 3 references available
Quantity 100 μL
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Catalog No. ABIN969145
253.00 $
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Immunogen Purified recombinant fragment of Fibulin 5 expressed in E. coli.
Clone 3F8D5
Isotype IgM
Purification Ascites
Alternative Name Fibulin 5
Background Synonyms:
EVEC, UP50, ARMD3, DANCE
Fibulin 5 (FBLN5), with 448 AA protein (about 50 kDa), is a recently discovered multifunctional extracellular matrix protein that mediates endothelial cell adhesion through integrin ligation, regulates cell growth and motility in a context-specific manner, and prevents elastinopathy in vivo. Fibulin-5 is abundantly expressed in great vessels and cardiac valves during embryogenesis, and in many adult tissues including the aorta, lung, uterus and skin, all of which contain abundant elastic fibres. Decreased fibulin-5 may contribute to the pathogenesis of aortic dissection by impairing elastic fiber assembly. Fibulin-5 is also a good marker of skin ageing and that the earlier loss of fibulin-5 may involve age-dependent changes in other elastic fibre components.
Gene ID 10516
Research Area Cardiovascular, Atherosclerosis, Extracellular Matrix
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-Fibulin 5 (FBLN5) antibody Figure 1: Western blot analysis using fibulin5 mouse mAb against truncated fibulin5 recombinant protein (1) and Hela cell lysate (2) .
Product cited in: Lee, Roy, Mogford et al.: "Fibulin-5 promotes wound healing in vivo." in: Journal of the American College of Surgeons, Vol. 199, Issue 3, pp. 403-10, 2004 (PubMed).

Wen, Hochholdinger, Sauer et al.: "The roothairless1 gene of maize encodes a homolog of sec3, which is involved in polar exocytosis." in: Plant physiology, Vol. 138, Issue 3, pp. 1637-43, 2005 (PubMed).

Kadoya, Sasaki, Kostka et al.: "Fibulin-5 deposition in human skin: decrease with ageing and ultraviolet B exposure and increase in solar elastosis." in: The British journal of dermatology, Vol. 153, Issue 3, pp. 607-12, 2005 (PubMed).

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