PRKDC antibody (Protein Kinase, DNA-Activated, Catalytic Polypeptide)

Details for Product anti-PRKDC Antibody No. ABIN969366, Supplier: Log in to see
Antigen
  • PRKDC
  • AI326420
  • AU019811
  • DNA-PKcs
  • DNAPDcs
  • DNAPK
  • DNPK1
  • DOXNPH
  • HYRC1
  • XRCC7
  • dxnph
  • p460
  • scid
  • slip
  • HYRC
  • p350
  • dna-pkcs
  • dnapk
  • dnpk1
  • hyrc
  • hyrc1
  • prkdc-A
  • xrcc7
  • DNA-PKCS
  • protein kinase, DNA-activated, catalytic polypeptide
  • protein kinase, DNA activated, catalytic polypeptide
  • PRKDC
  • Prkdc
  • prkdc
Alternatives
anti-Human PRKDC antibody for Dot Blot
Reactivity
Human
412
156
58
13
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2
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2
1
1
1
Host
Mouse
316
100
3
1
Clonality (Clone)
Monoclonal ()
Conjugate
This PRKDC antibody is un-conjugated
21
19
17
9
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8
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7
7
7
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7
5
5
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
203
140
109
107
92
88
62
37
15
11
8
6
5
3
2
2
2
1
Options
Supplier
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Available images

Immunogen Purified recombinant fragment of human PRKDC expressed in E. Coli.
Clone 3H6
Isotype IgG1
Purification Ascites
Alternative Name PRKDC (PRKDC Antibody Abstract)
Background The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity, PRKDC must be bound to DNA to express its catalytic properties.
Molecular Weight 46.9 kDa
Gene ID 5591
HGNC 5591
Pathways DNA Damage Repair, Production of Molecular Mediator of Immune Response
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
ELISA image for anti-PRKDC antibody (Protein Kinase, DNA-Activated, Catalytic Polypeptide) (ABIN969366) Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 n...
Immunocytochemistry (ICC) image for anti-PRKDC antibody (Protein Kinase, DNA-Activated, Catalytic Polypeptide) (ABIN969366) Figure 2: Immunofluorescence analysis of Hela cells using PRKDC mouse mAb (green) . R...
Immunohistochemistry (IHC) image for anti-PRKDC antibody (Protein Kinase, DNA-Activated, Catalytic Polypeptide) (ABIN969366) Figure 3: Immunohistochemical analysis of paraffin-embedded breast cancer (left) and ...
Immunohistochemistry (IHC) image for anti-PRKDC antibody (Protein Kinase, DNA-Activated, Catalytic Polypeptide) (ABIN969366) Figure 4: Immunohistochemical analysis of paraffin-embedded lung cancer (left) and br...
Western Blotting (WB) image for anti-PRKDC antibody (Protein Kinase, DNA-Activated, Catalytic Polypeptide) (ABIN969366) Figure 5: Western blot analysis using PRKDC mAb against HEK293 (1) and PRKDC (AA: 263...
Product cited in: Durkin, Guo, Fryrear, Mihaylova, Gupta, Belgnaoui, Haoudi, Kupfer, Semmes: "HTLV-1 Tax oncoprotein subverts the cellular DNA damage response via binding to DNA-dependent protein kinase." in: The Journal of biological chemistry, Vol. 283, Issue 52, pp. 36311-20, 2008 (PubMed).

Huston, Lynch, Mohamed, Collins, Hill, MacLeod, Krause, Baillie, Houslay: "EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 35, pp. 12791-6, 2008 (PubMed).