APOE antibody (N-Term)
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- Target See all APOE Antibodies
- APOE (Apolipoprotein E (APOE))
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Binding Specificity
- N-Term
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Reactivity
- Human, Mouse, Rat, Zebrafish (Danio rerio)
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This APOE antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- LMDETMKELK AYKSELEEQL TPVAEETRAR LSKELQAAQA RLGADMEDVC
- Predicted Reactivity
- Human: 100%, Mouse: 93%, Rat: 93%, Zebrafish: 77%
- Characteristics
- This is a rabbit polyclonal antibody against APOE. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product APOE Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 317 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- APOE (Apolipoprotein E (APOE))
- Alternative Name
- APOE (APOE Products)
- Synonyms
- ad2 antibody, apoprotein antibody, im:7036787 antibody, wu:fb69a05 antibody, zgc:110064 antibody, apoe antibody, AI255918 antibody, AD2 antibody, LDLCQ5 antibody, LPG antibody, APOEA antibody, Apo-E antibody, apolipoprotein E antibody, apolipoprotein Ea antibody, apoe antibody, apoea antibody, Apoe antibody, APOE antibody
- Background
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Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
Alias Symbols: AD2, LDLCQ5, LPG, MGC1571
Protein Interaction Partner: LCAT, ARFGAP1, ALB, C19orf52, LOXL4, PRAM1, MID1IP1, ANKH, FBXL12, FXYD7, ECSIT, PDCD4, IFIT5, MAST1, EPN2, PLEKHA6, CDC37, IQSEC1, LONP1, TYRO3, PRDX2, ST13, RPL4, RHEB, PSEN1, HTRA1, PCMT1, ZNF558, NOS3, IFIT3, GCDH, FOXG1, FARSA, ELAVL1, CYP2C18, CYP2C
Protein Size: 317 - Molecular Weight
- 34 kDa
- Gene ID
- 348
- NCBI Accession
- NM_000041, NP_000032
- UniProt
- P02649
- Pathways
- Regulation of Cell Size, Lipid Metabolism
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